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Pregnant women should not be routinely
screened and treated for an infection that is associated with
an increased risk of preterm delivery, new study findings
suggest.
In the study, pregnant women who received
the drug metronidazole (Flagyl) for a vaginal infection known
as asymptomatic vaginal trichomoniasis, were nearly twice
as likely to deliver their babies early, compared
with women who received an inactive medication or placebo.
The investigators found that 19% of the
women who received the drug delivered their baby before 37
weeks' gestation.
Only 11% of the women who took the placebo
experienced preterm delivery. A full-term pregnancy is 40
weeks, but delivery anywhere from 38 weeks to 42 weeks is
considered safe.
Routine screening and treatment of symptomless
pregnant women for this condition cannot be recommended, the
researchers concluded. The majority of women who have vaginal
trichomoniasis -- a sexually transmitted infection -- do not
have symptoms, which can include vaginal discharge and burning.
Because the infection in pregnant women
has been linked to an increased risk of preterm delivery and
low birth weight infants,
screening and treating the infection during pregnancy has
been recommended, although it was unclear whether the treatment
reduced the risk of early delivery.
The New England
Journal of Medicine August 16, 2001 ;345:487-493
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