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Babies born prematurely are typically given a nutrient-enriched form of infant formula to help them grow. However, a study found that these infants are more likely to have a pre-diabetic condition in adolescence.
On the contrary, researchers have also found that pre-term infants who are given extra nutrition during the rapid growth period of the first few weeks of life, helps to develop the brain and bone.
Researchers say that the risks of developing diabetes or problems in the brain and bone are likely different in individual infants. Since the evidence is conflicting, they say it's probably wise to continue feeding premature babies a nutrient-rich diet.
Additionally, researchers stressed that while the study points to risks of feeding premature infants too much, infants should not be underfed.
The study followed 216 people born prematurely and 61 people born full-term from birth until their teenage years. Half of the teens born prematurely had been fed a standard diet consisting of unsupplemented breast milk and standard, non-enriched infant formula while the others were fed a nutrient-enhanced formula designed for premature infants.
Teens born prematurely who received the nutrient-enriched diet tended to have higher levels of proinsulin than teens born prematurely who received a standard diet.
High levels of proinsulin may indicate that a person has insulin resistance, a condition that often leads to type 2 diabetes, which is associated with obesity.
Further, teens, whether born prematurely or not, who gained weight more quickly than others during the first two weeks of life also tended to have high proinsulin levels.
The reason why rapid growth during the early life of premature infants may potentially increase the risk of diabetes remains unclear, however researchers noted that factors employed during early life can have long-term effects.
The Lancet 2003;361:1089-1097
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