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| Cholesterol
collects in the blood |
Increasing levels of 'good' cholesterol may be more beneficial than
reducing bad cholesterol, according to a study.
Doctors have long been focusing on decreasing either total cholesterol
or the proportion of low-density lipoprotein (LDL), which is the
harmful cholesterol that damages arteries and causes heart disease.
However, the study showed that heart disease deaths decreased when
patients took drugs to raise high-density lipoprotein (HDL), the
healthy fat found in blood.
While cholesterol, which is produced by the liver, is vital for
certain cellular functions, if too much LDL is in the bloodstream,
it can damage blood vessel lining and increase the risk of clots.
Many studies have examined the benefits of reducing LDL, however
few studies have looked into the benefits of raising HDL.
The current study tracked about 3,000 patients for an eight-year
period. Half received a daily dose of bezafibrate, a drug used to
control cholesterol levels in heart disease, while the other half
received a placebo pill.
After the study, more than 15 percent of the placebo group had
died from heart disease, compared with 13.9 percent of the drug
group.
Further, HDL levels among those in the drug group increased 17
percent while HDL levels in the placebo group rose only three percent.
The results indicate that people treated with fibrates benefit
from increases in their HDL levels, according to researchers. However,
they noted that not all patients respond to such therapy, and those
who did not respond were worse off than those on the placebo.
BBC
News April 5, 2003
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