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Drugs commonly
prescribed to osteoporosis and cancer patients may cause serious
inflammation in several regions of the eye in some patients.
Researchers hope the finding will make physicians more likely
to monitor patients for such eye problems as well as prompt
drug companies to add warning labels to their products.
Two medications
in a class of drugs called bisphosphonates, which are often
used to increase bone density in patients with osteoporosis,
were found to cause the serious side effects in the eyes of
some patients. The drugs are also prescribed to cancer patients,
as lung, breast or prostate cancer that has spread to the
bones can also decrease bone density.
Researchers reviewed
thousands of cases in which patients were prescribed bisphosphonates
and tracked 314 patients who also reported eye problems. Although
the side effects were rare and did not occur in most patients,
some types of eye inflammation can lead to vision loss or
blindness if left untreated.
Of the patients
who reported side effects, close to 100 suffered from blurred
vision. Other problems included pain and swelling.
Researchers noted
that the side effects went away when patients stopped taking
the medication.
New
England Journal Medicine March 20, 2003;348(12):1187-8
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