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A new cholesterol-lowering statin drug, Crestor, will soon
be hitting the market, joining its highly successful competitors
Lipitor and Zocor. In 2002, statin drugs brought in $13 billion
in sales. At least 12 million U.S. adults take cholesterol-lowering
drugs.
Crestor, known generically as rosuvastatin, is manufactured
by AstraZeneca. The drug may be slightly better than other
statins at raising good cholesterol levels and may also be
more powerful than the other statin drugs.
However, the highest, 80-milligram dose of Crestor could
not be approved because of serious side effects including
muscle and kidney damage. Some say the drug may produce side
effects even at lower doses, and caution that patients should
be closely monitored when on the drug.
All statin drugs can cause an increase in liver enzymes so
patients must be monitored for normal liver function. Statins
can also cause muscle aches, weakness and, rarely, a dangerous
degenerative muscle tissue condition called rhabdomyolysis.
Washington
Post August 12, 2003; Page HE01
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