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By
Brian Vonk, M.D.
You may have gotten
to a point in your life where you're asking, "Where is
my health going and why am I in this handbasket?" Or
you may be saying, "I feel fine and want to make sure
I stay that way."
The fact is, the
majority of Americans older than 40 years already have a major
health problem. Another disconcerting fact is that the majority
of illnesses are subclinical, meaning they smolder under the
surface for many years before they are recognized. Whatever
your condition, sickness or apparent health, accurately assessing
your current health is the proper place to start on your journey
to vibrant health.
Since cardiovascular
health is key to health in general -- and the lack of it is
so common -- it is where I'd like to begin a health review.
Heart disease is the #1 killer of Americans, followed, in
order of prevalence, by cancer, stroke, emphysema, and accidents.
But every 34 seconds
an American dies of heart disease!
Consequently, we
all know someone with heart disease, or we have it ourselves.
If you're interested in avoiding or ending personal experience
with this disease, I have good news for you: the majority
of the causes of cardiovascular disease are in our control.
The first and foundational
step in gaining or maintaining cardiovascular health is accurately
measuring your current condition. Once that is clearly understood,
an effective treatment or preventative plan can be made. In
this article, we'll review the most important factors indicating
cardiovascular health or disease. Collect the information
and grade yourself.
Blood
Analysis
Most of us have
had our blood drawn to determine our cholesterol level. That
number alone, however, is actually quite useless.
There is a huge
amount of misinformation about cholesterol, leaving most people
thinking it is the grinch who steals youthful vitality. The
truth is cholesterol is vital for health and we'd all be dead
without it.
We get disease
if cholesterol is too high or too low. But in the broad range
of cholesterol levels from 180 to 240 there is no correlation
with heart disease. Below 180 there is increased risk of hemorrhagic
stroke, depression, and suicide. Above 240 there is increased
risk of cardiovascular disease and ischemic stroke. Over age
70, elevated cholesterol and cardiovascular events no longer
correlate. All told, total serum cholesterol alone is a poor
indicator of cardiovascular disease. Half of all heart attack
patients have normal total cholesterol levels.
So
why are doctors recommending statin drugs for cholesterol
levels above 200?
Ask the pharmaceutical
companies who sponsor the drug studies and also help determine
what normal cholesterol levels are. The upper limit of normal
total cholesterol recently went down from 220 to 200, creating
"disease" in additional millions of Americans. How
convenient that the drug companies just so happen to have
the "cure" for that disease!
I want to help
you avoid that treatment trap. In fairness, compared to many
drugs, most of the statin drugs are some of the safer drugs
you might take and actually have the beneficial effects of
being powerful antioxidant and anti-inflammatory agents. These
beneficial features are likely the reason studies show decreased
cardiac deaths when they are used.
Nevertheless, the
statin drugs' potential side effects are significant. In some
they deplete coenzyme Q 10 within the liver enough to cause
liver enzyme elevations and within the muscles to cause myopathy.
Also, and this is not published to my knowledge, but in my
and several of my physician colleagues' experiences, statins
cause depression or loss of motivation in the majority of
patients, probably due to alteration of cholesterol metabolism
in the brain. As a result, many of these patients are also
on SSRI (selective serotonin reuptake inhibitor) drugs (eg
Zoloft, Paxil, Prosac).
What
is it worth to you to avoid depression and loss of motivation?
There are far safer
ways to decrease cardiac deaths and treat abnormal cholesterol
levels without risking drug side effects. Depite this, you
would be astounded how many patients would rather take a pill
with potential severe side effects than consider changing
anything else.
As noted above,
total serum cholesterol doesn't correlate with cardiovascular
disease in the range of 180 to 240 but certain fractions of
that total cholesterol do correlate. These fractions are HDL
and LDL cholesterol. This is why you need a Lipid Profile
(also called a Lipid Panel) and not just a total cholesterol
when you get your blood drawn.
I have compiled
two tables below listing the components of cholesterol (ie
the Lipid Profile) as well as listing several other markers
for cardiovascular health and disease. The first table has
the usually quoted normal levels and the second table has
ideal levels. Normal levels can change depending upon the
levels found in the majority of the population as well as
upon what health officials decide is normal. Ideal levels
are those which reflect health. We want the ideal levels for
optimal wellness not just normal.
All of the markers
listed in the tables are important. For example, you can have
normal HDL/Chol ratio, normal homocysteine, normal fasting
glucose, but have ferritin outside the ideal range and have
cardiovascular disease as a result. It only takes one rascal
to spill the beans.
Cardiovascular
Disease Markers:
These are the declared
"normal" levels that your doctor will use to tell
you whether your various serum/blood levels are "normal"
(NOTE: These levels do NOT necessarily
mean healthy levels, rather these will include healthy and
many very unhealthy patients):
| "Normal"
levels |
|
Total Cholesterol (mg/dL) |
Normal range = It changes with age but quite accurate:
= Upper level is 230 + age, Max 300
= Lower level is 115 + age
Recommended cholesterol level is a moving target. Recently
cardiologists are recommending everyones level should
be below 200 at all ages. |
| HDL
Cholesterol (mg/dL) |
Normal range = Males 30-70, Females 35-80 |
| LDL
Cholesterol (mg/dL) |
Normal range = 60-150 below age 20
= 70-180 age 30-50
= 80-210 above age 50 |
|
Triglycerides
(mg/dL)
|
Normal range = It changes with age but quite accurate:
= Males upper level is 130 + age, Max 200
= Females lowerlevel is 80 + age, Max 165
= Males/Females lower level is your age |
|
C-Reactive
Protein(CRP)
|
Normal range = Below 10 mg/L (1 mg/dL)
|
|
Homocysteine
|
Normal range = Below 17 micromoles/L
|
|
Lipoprotein
a (Lp a)
|
Normal range = Below 25 mg/dL |
|
Ferritin
|
Normal range = Males 20-300, Females 15-120 ng/ml
Iron overload = Above 400 ng/ml |
|
Fibrinogen
|
Normal range = Males 180-340, Females 190-420 mg/dL |
|
Blood
glucose(8hr fast)
|
Normal = <120 mg/dL Borderline DM = 120-140 mg/dL
Diabetic = Above 140 mg/dL (W.H.O. definition)
|
|
Insulin
(8 hr fasting)
|
Normal = Below 20 microUnits/ml
Borderline DM = 21-25 microUnits/ml
Diabetic = Above 25 microUnits/ml |
| Hemoglobin
A1C |
Normal range = Below 7.5% of total hemoglobin |
The following serum
levels are the most IDEAL (ie. beneficial) levels for cardiovascular
(CV) health. Having any ONE of these outside the ideal range
can cause or indicate CV disease! These ideal or healthy levels
are much tighter than the often quoted "normal"
levels referred to by your doctor. Remember "normal"
does NOT necessarily mean "healthy". We want healthy,
not just normal:
| "Ideal"
levels |
|
Total Cholesterol*
|
Ideal
Range = 180 to 200 mg/dL if less than age 70
Ideal Range = Up to 300 if older than age 70 |
|
HDL
Cholesterol
|
Ideal
level = Above 50 mg/dL |
|
LDL
Cholesterol
|
Ideal
level = Below 100 mg/dL |
|
HDL
% or Ratios
|
Ideal
levels = See table below |
|
Triglycerides(TG)
|
Ideal
level = Below 100 mg/dL |
|
C-Reactive
Protein(CRP)
|
Ideal
level = Below 1 mg/L (0.1 mg/dL) |
|
Homocysteine
|
Ideal
level = Below 8.0 micromoles/L |
|
Lipoprotein(a)ieLp(a)**
|
Ideal
level = Below 10 mg/dL |
|
Ferritin
|
Ideal
range = 20-50 ng/ml (Above 80 is trouble) |
|
Fibrinogen
|
Ideal
range = 150-300 mg/dL |
|
Blood
glucose(8hr fast)
|
Ideal
range = 60-85 mg/dL
Pre-diabetic = 95-110 mg/dL
Diabetic = Above 110 mg/dL
Hypoglycemic = Below 60 mg/dL
Critical levels = Below 40 or Above 450 mg/dL |
|
Insulin
(8 hr fasting)
|
Good
level = Below 5 microUnits/ml
Best level = 2-3 microUnits/ml
High risk Diabetes= Above 10 microUnits/ml |
| Hemoglobin
A1C*** |
Ideal
range = Below 6% of total hemoglobin |
*
Cholesterol: It is not advisable to have total cholesterol
below 150 at any age due to increased risk for internal hemorrhage,
depression, and suicide.
Note:
A mneumonic to help you remember that LDL is the "BAD"
cholesterol: LDL = Low Down Loathsome cholesterol.
**
Lp(a): LDL + APO(a) = Lp(a). Artery blockage (plaque) is composed
of 90-100% Lp(a) NOT of ordinary cholesterol. Lp(a) is a substitute
for ascorbate (Vitamin C). If you are not getting enough Vitamin
C to produce collagen for tissue repair, when your arteries
become injured they cannot heal properly. If there is inadequate
Vitamin C, the next best way to repair your arterial injuries
is make a Lp(a) plaque to cover the injury. Unfortunately
the plaques tend to continue to grow. Simply removing plaque
without restoring the artery to health is like tearing a scab
off a wound. You do not want to remove the scab until after
the tissue underneath has started healing. Your body needs
sufficient Vitamin C so your arteries can heal. Elevated homocysteine
can also play a role here and is detrimental because it causes
the binding of Lp(a) to fibrin in very low concentrations
thereby encouraging plaque formation in the vessel walls.
*** HbA1C (also called glycosylated hemoglobin) correlates
well with your average blood sugar over the last 3 months.
Tight blood sugar control makes a HUGE difference in complications
in diabetics and prediabetics. When A1C levels are elevated
above 6.5, for every 1 percent reduction in A1C levels there
is a 14 percent to 40 percent decrease in diabetes-related
complications! Diabetics with A1C levels of 6.5 or lower only
need to have the test repeated every six months. Those with
higher levels should be tested every two to three months until
levels drop to 6.5 or lower, while they make corrections with
improved diet and additional diabetes medication. Most diabetics
have the disease for 10 years before it is diagnosed, but
it has silently been doing damage for all those years.
| Cholesterol
Cardiac Risk Factors |
| Cholesterol/HDL
Ratio (ie Total Cholesterol divided by HDL): |
| Cardiac
Risk |
Ratio
in Males |
Ratio
in Females |
| High
risk (3X): |
9.7
to 23.4
|
7.2
to 11.0 |
| Above
average risk (2X): |
5.1
to 9.6 |
4.5
to 7.1 |
| Average
risk: |
3.5
to 5.0 |
3.4
to 4.4 |
| Below
average risk (1/2): |
1.0
to 3.4 |
1.0
to 3.3 |
| HDL
Percentage: HDL/Cholesterol X 100 (ie HDL divided by Total
Chol X 100): |
| Cardiac
Risk |
HDL
in Males |
HDL
in Females |
| High
risk (3X): |
Below
10% |
Below
14% |
| Above
average risk (2X): |
10
to 19% |
14
to 22% |
| Average
risk: |
24%
(Range 20 to 29) |
26%
(Range 23 to 30) |
| Below
average risk (1/2): |
Above
29% |
Above
30% |
| LDL/HDL
Risk Ratio (ie LDL divided by HDL) Male or Female: |
| Cardiac
Risk |
Ratio
in Males |
Ratio
in Females |
| High
risk (3X): |
6.4
to 8.0 |
5.1
to 6.1 |
| Above
average risk (2X): |
3.7
to 6.3 |
3.3
to 5.0 |
| Average
risk: |
1.1
to 3.6 |
1.6
to 3.2 |
| Below
average risk (1/2): |
Below
1.1 |
Below
1.6 |
Besides obtaining
blood work, your doctor has other tests he can order to determine
your cardiovascular state including resting EKG, treadmill
stress test, CT coronary calcium scoring, echocardiogram,
nuclear medicine scans, and coronary angiography. These are
useful if you have known or suspected disease; however, as
you advance from non-invasive to invasive studies there are
increased risks for the tests themselves. There is a one in
one thousand chance of dying from a coronary angiogram. This
is an average. In your doctor's hands you may have a much
lower risk but it also could be much higher. These tests must
be used wisely.
You obviously need
to go to a doctor if you want to get the appropriate blood
work and the other procedures listed above. But there are
"low tech" and yet very useful evaluations you can
do on your own which also help determine your cardiovascular
risk.
The
"low-tech" cardiovascular evaluations
| Smoking:
The first evaluation is a simple question. Have
you smoked in the past twenty years? The more you
have smoked and the more recent the habit, the more
detrimental its effect. Chewing tobacco is also
injurious but not nearly as much as smoking. |
|
| Systolic
blood pressure: This is the top number of your blood
pressure reading. Above 140 mmHg the risk of cardiovascular
disease rises as the blood pressure rises. |
|
|
Ankle-Arm
Index: This is also called Ankle-Brachial Index
(ABI) and is the ratio of the ankle systolic blood
pressure* divided by the arm systolic blood pressure.
A normal index is 1.0 and below 0.9 indicates
cardiovascular disease.
I
mention this test because you may have heard of
it, but be aware that it has limited value. The
potential weakness of the test is that it tends
to be falsely normal in people with calcifications
in their arteries, people with diabetes, pre-diabetes,
or those with Vitamin K deficiency. Millions of
Americans are pre-diabetic or diabetic and most
of them don't even know it. Also, recent studies
indicate that significant Vitamin K deficiency
is becoming common.
So,
if the Ankle-Arm Index is normal you must exclude
these causes of arterial calcification before
you can assume the test is truly normal. If the
test is abnormal, you have some degree of cardiovascular
disease.
*
Ankle pressure is taken with the cuff just above
the ankle and the stethoscope listening just below
the cuff on the inner side of the ankle immediately
behind the ankle bone.
|
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| Resting
Heart Rate: An elevated resting heart rate is a
powerful indicator of cardiovascular disease in
men (however studies have not shown the correlation
in women). Healthy = Below 64 beats/min, Mild risk
= 64 to 69 beats/min, Moderate risk = 70 to 75 beats/min,
High risk = 76 to 80 beats/min, Above 80 beats/min
the risk is three times normal. |
|
| Heart
Rate Recovery: This test assesses how quickly your
heart rate returns to normal after exercise and
is quite useful in determining cardiovascular health.
This requires that you can reach 85% of your maximum
predicted heart rate (your maximum predicted heart
rate is calculated as 220 minus your age). If you
currently aren't accustomed to that degree of exercise,
you should get an exercise program from your doctor
or a fitness coach and build up to that level slowly.
Once you are able to reach that heart rate, you
stop the exercise and measure your heart rate 1
minute later. If the rate drops by 12 or less during
that minute the test is abnormal and there is significant
risk of cardiovascular disease. |
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Basal
Body Temperature: This is a test of your core
body temperature and is a very useful test to
determine if your thyroid hormonal system is underactive
(ie hypothyroid).
What
does being hypothyroid have to do with cardiovascular
disease?
Hypothyroidism
causes abnormal lipid metabolism which results
in accelerated cardiovascular disease. Cholesterol
and other lipids can become elevated due to diminished
function of lipid metabolism enzymes caused by
the lower body temperatures. Many body enzymes
are highly temperature dependent, malfunctioning
at abnormally low or high temperatures. The more
abnormal the temperature, the more malfunctional
the enzyme. On a molecular basis, this is why
we become listless as our body temperatures go
out of the normal range and we die at temperature
extremes.
Although
the frequency of hypothyroidism has been hotly
debated for many decades, I am convinced that
hypothyroidism is common and often unrecognized.
The official normal range of thyroid blood tests
are virtually useless except for obvious hypothyroidism
and hyperthyroidism. These blood tests are useful
if much tighter normal ranges are used. Additionally,
accurate assessments of thyroid function can be
obtained with basal body temperatures.
Ideally
body temperature is taken immediately upon awakening
and while still in bed, but it can be taken during
the day at least 15 minutes after eating or drinking
and when you haven't been exercising. Men and
post-menopausal women can take their temperatures
on any day but menstruating women have some restrictions.
Their temperature fluctuates with their menstrual
cycle, lowest at ovulation and highest just before
menstrual flow. They can most accurately measure
the temperature on the second and third day of
the period after the flow begins. Normal temperatures
are: Armpit 98.0 +/- 0.2, Oral 98.6 +/- 0.2, and
Rectal 99.0 +/- 0.2 degrees Fahrenheit.
Another
useful assessment is an exceedingly low-tech question,
"Do you tend to be very hot or cold when
most others are not"? Characteristically,
hypothyroid patients are very "cold blooded"
and are cold to their core even when wearing warm
clothes. As a corollary, these patients rarely
can create any significant sweat. As an aside,
two other conditions that can cause low body temperature
are adrenal exhaustion and profound hypoglycemia
but these diagnoses are usually quite obvious.
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| Gum
health: Do your gums bleed when you brush your teeth
even though you don't have a blood coagulation disorder?
If they do, you likely have either have periodontal
disease or Vitamin C deficiency or both. Either
condition predisposes you to cardiovascular disease. |
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Waist
size: There are many cardiovascular risk formulas
and ratios that use your waist measurement, but
one of the simplest is also one of the most accurate:
Your
waist size in inches should not be greater than
one half your height in inches. The greater your
abdominal girth relative to your height, the greater
your risk of cardiovascular disease.
Insurance
companies are good at making money because their
actuaries are very knowledgeable in determining
risks. Why do you think they insist on knowing
your height and waist measurements as part of
your insurance physical? Increased abdominal girth
is a strong indicator of hyperinsulinemia, pre-diabetes,
and diabetes and consequently a useful indicator
of cardiovascular disease.
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Summary: We have
reviewed several of the most important indicators of cardiovascular
health and disease. As Goethe aptly stated, what one knows,
one sees. You now have a knowledge of cardiovascular health
and disease that few others have. You are equipped to see
what most will overlook.
If you passed most
or all of these tests in flying colors, congratulations, your
risk of cardiovascular disease is very low.
If you underperformed
on many of these tests, now is the time to do something about
it. As long as there is life, there is hope. You will find
instructions on what to do about abnormal cardiovascular tests
in past and future articles here on the website, but the most
basic intervention always is maximizing our daily nutrition.
20%
Of Heart Attacks Go Undetected -- How Can You Check Your
Risks
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