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For the first time, a gene has been discovered that is linked
to atherosclerosis, a build-up of cholesterol in artery walls
that leads to most heart attacks and strokes--and, the gene’s
effect is controlled by diet.
A study was conducted on 470 healthy middle-aged people whose
diets were monitored for 18 months. Evidence pointed out that
the adverse effect of this gene, a variant form of a gene
called 5-lipoxygenase (ALOX5), was increased by dietary intake
of certain n-6 polyunsaturated fats, which are found in certain
meats and many vegetable oils, while the adverse effect was
blocked by intake of fish oils containing n-3 polyunsaturated
fatty acids.
The new finding indicates that a substantial proportion of
people carry a variant form of the 5-lipoxygenase gene, but
may be able to control its effect on heart disease by altering
their diets.
Science
Daily January 1, 2004
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