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A
recent study concluded thimerosal, a mercury preservative commonly
found in some childhood vaccines, can spur the development of autism-like
damage in autoimmune-disease- susceptible mice. This model is the
first to show low doses of mercury can lead to behavioral and neurological
alterations in developing brains. It also supports previous studies
demonstrating that environmental triggers and genetic factors affect
the risk of autism.
Interest in the link between mercury and autism isnt surprising,
because genetic factors alone dont account for the tenfold
climb in autism over the past two decades. Over the course of the
study, researchers found the mice exposed to thimerosal showed many
behavioral and neuropathological features of autism disorders:
- Larger brain sizes
- Limited ranges of behaviors in addition to a decreased
exploration of environments
- Abnormal responses to unique environments
- Deviations in brain architecture affecting areas that
control emotions and thought
The cumulative exposure to mercury through other sources, including
pre-birth exposure to fish, can also lead to damage. Why? The brain
can suffer from exposure to toxins that have disappeared long before
symptoms are noticed.
For the study, thimerosal testing on mice was developed by using
the nations immunization schedule for children, with doses
based on the weights of U.S. boys ages 1, 2, 4 and 6. Although thimerosal
is still used in some flu vaccines, its presence has been reduced
in the past few years, according to researchers.
Finding the link between genetic susceptibility and environmental
triggers for autism is important, researchers said, because it promotes
more research into effective safeguards that can limit or sidestep
exposure in specific age groups to thimerosal. The data is also
valuable in terms of comparing the results in mice to human babies,
and dissecting the interaction between the environment and genes
over time.
Molecular
Psychiatry June 8, 2004
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