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Mild
cognitive impairment (MCI) among the elderly had been previously
viewed as relatively benign, however now experts believe it should
not be viewed as a normal part of the aging process, but rather
as the beginning of a far more serious disease process. A recent
study found that even minor loss of cognitive function appears to
be an indicator of one or both of the neurologic diseases Alzheimer's
or cerebral vascular disease.
In the study, which involved following subjects until they developed
mild cognitive impairment or dementia and then died, participants
took tests that measured their memory, language, attention and other
cognitive abilities each year. After death, the researchers examined
brain tissue from 180 people--37 with mild cognitive impairment,
60 without cognitive impairment and the rest with dementia--and
measured the amount of Alzheimer's disease pathology and cerebral
infarcts (strokes). It was found that:
- More than half of the 37 people with
MCI met pathologic criteria for Alzheimer's disease.
- Close to one-third of those with MCI
had cerebral infarcts.
- Less than one-quarter of the participants
had neither of the pathologies.
On a positive note, researchers found that one-third of those with
an average age of 85 did not experience signs of cognitive decline,
despite the fact that half of them had significant Alzheimer's disease
pathology and close to one-quarter had cerebral vascular disease.
Researchers believe these people have a sort of "reserve capacity"
that allows them to stay cognitively sharp even though their brains
showed signs of disease.
However, the number of people who experience cognitive impairments
because of Alzheimer's disease and cerebral vascular disease is
likely much larger than estimates show, researchers said.
Neurology
March 8, 2005; 64:834-841
Science
Daily March 17, 2005
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