Researchers have provided solid evidence that dietary changes
may offer an alternative approach to treating and preventing Alzheimer's
disease--a chronic form of dementia, which results in severe memory
loss and eventually death.
Specifically, studies indicated that a low carbohydrate diet that
reduced total caloric intake by 30 percent prevented the formation
of amyloid plaque development in a strain of mice genetically engineered
to develop the disease. Amyloid plaque development is a primary
problem associated with Alzheimer's.
Through testing, researchers found:
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Mice did not develop the physiological markers of Alzheimer's
when fed a restricted diet that provided 70 percent of the calories
eaten by similar mice that were allowed to eat as much and as
often as they pleased, or ad-lib
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There was 100 percent amyloid plaque development in mice fed
ad-lib
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No plaque development occurred in mice that were fed a restricted
diet
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The restricted diet activated pathways responsible for breaking
down amyloidogenic beta-amyloid peptides in the brain before
they are able to form plaque
Further, not only did the restricted diet prevent Alzheimer's,
it also allowed the mice to maintain a healthy weight. Thus, a mild
change in diet resulted in an astonishing measure of disease prevention.
Though the reduced intake of calories proved to be beneficial to
mice, researchers explained it is too early to determine specific
dietary recommendations for humans.
The
FASEB Journal January 13, 2005
Science
Blog January 12, 2005
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