Thanks to a discovery by Korean researchers, the number of weapons
in the arsenal to fight Parkinson's disease has just gotten bigger.
According to research, a biologically active form of vitamin D,
known as 1,25(OH)2 D3, works like a natural anti-inflammatory to
prevent the disease.
However, 1,25(OH)2 D3 wields most of its actions only after it
binds to its specific nuclear receptors.
A Vitamin D Discovery
Researchers set out to determine if vitamin D receptor gene (VDRG)
BsmI polymorphisms were markers for the susceptibility to Parkinson's
in Korean patients. The study involved 85 Parkinson's patients (30
men and 55 women) and a control group of more than 200 healthy patients:
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Those in the Parkinson's group were evaluated by a neurologist
and diagnosed with idiopathic Parkinson's disease on the presence
of two or more chief characteristics of the disease (i.e. tremor,
rigidity and bradykinesia), as well as by the lack of signs
not related to Parkinson's.
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Patients in the control group were screened to ensure they
had no history of neurological and psychiatric disorders.
Each polymorphism was detected using polymerase chain reaction
(PCR)-based restriction analysis; the relationship between the BsmI
polymorphisms and the clinical manifestations of Parkinson's was
also evaluated.
The results of the study showed that overexpression of the b allele
and homozygote bb caused the VDRG of Parkinson's patients to react
differently than those in the control group--thus making them more
susceptible to this devastating disease.
Journal
of Korean Medical Science June 2005;20(3):495-98 (Free Full-Text
Article)
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