Women may want to think twice before using plastic food containers
and cans, for a study found a chemical widely used in such packaging--known
as bisphenol-A, or BPA--may be linked to the incidence of breast
cancer.
Researchers reported persistent alterations to mammary gland development
after giving doses of the compound to pregnant mice that were designed
to mirror human exposure levels. Experiments suggested mammary glands
of female mice grew in a way that made them more susceptible to
breast cancer development and also to respond unusually to estrogen--which
fuels most breast cancer in humans.
Toxic Exposure
The mice involved in the study were treated late in pregnancy and
about four days after birth; the offspring were examined when they
reached puberty about a month later. Due to BPA exposure, researchers
found:
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Large increases in the number and density of terminal end buds,
part of the mammary gland structure where breast tumors originate
in both animals and humans.
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A decrease in the ability to get rid of damaged cells that
could be cancerous.
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Mice exposed to higher doses of the compound developed mammary
glands more sensitive to estrogen.
What’s more, while the results of the study are indeed concerning,
they are not the first to highlight the negative health consequences
of widely used chemicals: Research has also found that phthalates
(also found in plastics) affect the genital development of baby
boys.
Endocrinology
May 26, 2005
The
Guardian May 30, 2005
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