A government-financed study comparing a variety of drugs used to treat schizophrenia has demonstrated that highly hyped newer drugs are little better, if at all, than older and cheaper medicines.
All Five Work, None Work Well
The study looked at four new-generation drugs, known as atypical antipsychotics, and one older drug. All five blunted the symptoms of schizophrenia, although three-quarters of the patients eventually stopped taking the drugs because of problems with side effects.
One of the newer drugs, Zyprexa, did help patients control symptoms for longer than the other drugs did, but also had a higher risk of serious side effects, including an increased diabetes risk.
Almost 1,500 people with the disorder participated in the study, which examined how long the drugs could be effectively used in real-world situations. After 18 months, 64 percent of the patients taking Zyprexa had stopped, and at least 74 percent had quit each of the other medications. Reasons for stopping use of the drugs included their being ineffective, intolerable side effects, or neurological symptoms such as stiffness and tremors.
Big Profits, Big Costs
The new drugs garner $10 billion in sales annually and account for 90 percent of all antipsychotics sold nationally.
The study is likely to have a great effect on state Medicaid programs, many of which are short on funds; the newer drugs cost three to 10 times more than the older drugs. The National Center for Policy Analysis estimates that Medicaid programs spend over $3 billion a year on antipsychotics, more than for any other class of drug.