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May 08 2008
Medicine`s Dirty Little Secret

doctor, secretThere's one medical statistic doctors don't much talk about despite its importance. It's called number needed to treat, or NNT. It’s a measure developed in the past 20 years, and it’s one of the best-kept statistical secrets in medicine.

The idea of NNT is simple enough. Most clinical trials look at how much better people do on a particular medicine. NNT answers the question: How many people have to take a particular drug to avoid one incidence of a medical issue (such as a heart attack, or recurrence of cancer)? For example, if a drug had an NNT of 50 for heart attacks, then 50 people have to take the drug in order to prevent one heart attack.

That doesn’t sound like a lot, so pharmaceutical companies tend to keep the number quiet and focus on broader, U.S. population-based statistics. But that could be changed if you ask for the NNT up front the next time you're handed a prescription.

Dr. MercolaDr. Mercola's Comments:
When the NNT statistic was first developed in 1988, it was intended to help you make a decision about whether or not to take a drug. After all, having it put in simple terms such as “Out of every 50 people who take this drug, perhaps one heart attack will be prevented, and the other 49 people will receive no benefit,” puts things into perspective … a perspective that the drug companies do not want you to see.

One of the most blatant examples of how drug companies have hidden NNT for their own self-serving purposes lies with cholesterol drugs. These drugs, which can cause side effects like liver damage, muscle weakness, cognitive impairment and many, many others, are touted as miracle pills that can slash your risk of a heart attack by more than one-third.

Well, BusinessWeek actually did a story on this very topic earlier this year, and they found the REAL numbers right on Pfizer’s own newspaper ad for the cholesterol-lowering drug Lipitor.

Upon first glance, the ad boasts that Lipitor reduces heart attacks by 36 percent. But there is an asterisk. And when you follow the asterisk, you find the following in much smaller type:

"That means in a large clinical study, 3% of patients taking a sugar pill or placebo had a heart attack compared to 2% of patients taking Lipitor."

What this means is that for every 100 people who took the drug over 3.3 years, three people on placebos, and two people on Lipitor, had heart attacks. That means that taking Lipitor resulted in just one fewer heart attack per 100 people.

The NNT, in this case, is 100. 100 people have to take Lipitor for more than three years to prevent one heart attack. And the other 99 people, well, they’ve just dished out hundreds of dollars and increased their risk of a laundry list of side effects for nothing.

Not to mention that this study was funded by the industry, which means their results may already be skewed, and the actual benefit may be even LESS than what they found.

Many Drugs are “Worse Than a Lottery Ticket”

According to Dr. Nortin M. Hadler, professor of medicine at the University of North Carolina at Chapel Hill, in Business Week:

"Anything over an NNT of 50 is worse than a lottery ticket; there may be no winners."

Well, the NNT for some cholesterol-lowering drugs has been figured at 250 and up, even after taking them for five years!

"What if you put 250 people in a room and told them they would each pay $1,000 a year for a drug they would have to take every day, that many would get diarrhea and muscle pain, and that 249 would have no benefit? And that they could do just as well by exercising? How many would take that?" Dr. Jerome R. Hoffman, professor of clinical medicine at the University of California at Los Angeles, asked Business Week.

The answer, of course, is few to none. And that is exactly why you have probably never heard of NNT before.

The Moral of the Story: Don’t Trust the Drug Companies

They have many tricks up their sleeves other than NNT, and they are masters at twisting the results of their studies to appear in a positive light.

So anytime you hear about how great a drug is, be very suspicious. You wouldn’t simply buy a car without finding out the real bottom line, right? So don’t blindly accept the numbers that the drug companies peddle either.

One thing you can do is ask your doctor or pharmacist to tell you the NNT for any prescription you’re considering. Even better is to assume that most drugs offer little benefit, and only take them as an absolute last option.

You have the power to take control of your health and thrive without the need for drugs. The drug companies want you to believe otherwise, but now you too know better.

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Community Comments ( 61 )
Comment on this Article
  
  
Christopher Gussa "The Herb Doc"
[ Joined on 11/06 ] [ Posted on April 18, 2008 ]
25 Points        
   
 
Moderator User

I always new there had to be tracking numbers like this. I am sure this is only the tip of the iceberg! I would bet there are some coed names to more specific stuff like cancer risk factor and things that would absolutely scare people from ever drinking from the “sorcerer’s cup” again! Dam evil bunch of demonic scientists! If justice were served I am sure there would be hundreds of pharma pigs guilty of first degree mass murder! Why can’t we all be judge and jury and do what is right, Cut the heads off these evil vipers!


Have a nice day! Peace Love Dove!

 [ Reply ]
Mercola
  
Jokes
[ Joined on 08/07 ]  [ Posted on May 8, 2008]
       
   
Novice User
  Mercola

I would like to email the HERB DR<. I am very interested in herbs for health and diabetes. Maybe he has some info I can use or a newsletter or group .. Jodell

Mercola
  
Activity Cures Everything
[ Joined on 06/06 ]  [ Posted on May 8, 2008]
1 Points        
   
Novice User
  Mercola

HEY JOKES!

Please go to www.plantcures.com. This will change your life! It is the "Herb Doc's" website. (Hope that's okay Herb Doc!)

Stay healthy!

Marco from Dallas!

Mercola
  
KelleyEidem
[ Joined on 11/07 ]  [ Posted on May 8, 2008]
       
   
Novice User
  Mercola

How can this happen? The signature wishes us Peace and Love, while the final sentence commands, "Cut off the heads of these vipers!" It sounds like something that terrorists do.

And yet the message gets posted?? Who is screening these things?

I, for one, can't stand the drug industry. I don't take any drugs, and I do my best to get others off their drugs. But the discourse presented above isn't just beyond the pale...it's off the charts.

Mercola
  
BarbaraAnn
[ Joined on 02/07 ]  [ Posted on May 9, 2008]
       
   
Novice User
  Mercola

Yeah.....but still no way to e-mail 'reply' on his website....

Like his Attitude, tho'

Barbara

  
  
PPARGammaGirl
[ Joined on 06/06 ] [ Posted on May 8, 2008 ]
14 Points        
   
 
Savvy User

Pick a parameter, any parameter, use a bell curve to classify people above, in or below “normal range” and then associate it with a catastrophic event like heart attack or stroke. Current parameters in use are cholesterol, blood pressure, bone mineral density, and many others. When enough people are convinced they need a synthetic drug to “prevent” said catastrophic event (even though the NNT might be as high as 800) the only way to expand your market is to revise “numbers” up or down to ensure many more people fall into the “pathology” category. Then throw in increasingly sensitive screening technology and we can all have a disease – don’t worry – plenty to go round.

 [ Reply ]
  
  
sleepybob
[ Joined on 09/07 ] [ Posted on April 21, 2008 ]
11 Points        
   
 
Novice User
So, NNT is basically a measure of effectiveness? If the number is 50, thats basically saying that its 2% effective at doing what it's supposed to do? How would they determine if someone is going to have an incidence to even prevent?
 [ Reply ]
Mercola
  
seg
[ Joined on 11/06 ]  [ Posted on April 22, 2008]
13 Points        
   
Savvy User
  Mercola
Or saying it another way Not  Necessarily True
  
  
Rett
[ Joined on 11/06 ] [ Posted on May 8, 2008 ]
8 Points        
   
 
Novice User

From my experiences over the last years since I have educated myself about my own health issues, I find that people are terrified to not do what their doctors say.  I've had two doctors send me certified letters giving me 30 days because I refused to take statins, blood thinners, ACE inhibitors, whatever.  My own husband shakes his head at my determination to not get trapped again in the big pharma lies. He is retired military and we can get almost any prescription filled with no out of pocket expense.  I want Dr. Mercola's book so I can learn more about how to reverse T2 Diabetes but this has become a thorn in my husband's side because he ain't buying it.  He watches Fox News all the time. The big pharma has the media to continually feed their viewers into believing the big pharma people care about them.  Fear is used to maintain that loyalty that will lead them to destruction like sheep to the slaughter.  It's about big money, not about optimal health.  Thank you, Dr. Mercola, for giving me a place where I can recover my sanity and be satisfied that there are many like you who want to educate us because you care.  

 [ Reply ]
Mercola
  
PatriSpain
[ Joined on 07/07 ]  [ Posted on May 8, 2008]
5 Points        
   
Novice User
  Mercola

I sympathize with you...I think the best you can do is be your own best example.  Don't worry about changing your husband...that is his decision.  And since you mentioned that he is an ex-military person, these people feel more comfortable following orders from authority.  They are trained not to think for themselves, but to follow orders and serve authority unquestioningly.  As macho as they can be, they are really just sheep of the worse kind.  They glorify the government and over trust it or any other authority such as the medical industry, media etc. 'If it was bad for you, the government wouldn't allow it' is common 'military people speak'.

Just take care of yourself and don't worry.  Your husband has made is decision.  Perhaps he will be more open at some distant point.

Mercola
  
Theresa J.
[ Joined on 10/06 ]  [ Posted on May 8, 2008]
2 Points        
   
This user is BELOW novice level and all their comments need to be reviewed with great caution.
  Mercola

Sometimes that's just the way people think; doctors are supposed to help us and free prescriptions are great.  Doesn't mean the military brainwashed them.  Many military people do think for themselves, lumping them all together is just as ignorant as what your assumption is. People are individuals, PatriSpain, no matter what group they affiliate with. The VA gave my husband pain pills for his back, but he cannot take them and work (do not operate heavy equipment while on these meds, what do you think his job entails?), the pills went in the trash and he continues to see chiro and naturo docs. Please do not assume! Glorify the government? where is your proof on that? pu-leaze!

  
  
4Hand Healthy
[ Joined on 06/07 ] [ Posted on April 22, 2008 ]
7 Points        
   
 
Apprentice User
I wonder how many other little secrets the drug companies hide on a regular basis.Dirty rotten scoundrels!!This only proves what "mercolians" and others have warned us about for years; you can't trust the drug companies or some doctors to take care of you.Take control of your own health.
 [ Reply ]
  
  
Think First
[ Joined on 02/08 ] [ Posted on May 8, 2008 ]
5 Points        
   
 
Novice User

I personally am a little stunned by some of the folks still buying into the whole cholesterol is evil myth. Your body needs to produce the proper amount for the hormones it needs to function normally. Your brain needs it to produce the chemicals and housekeeping to to stay sharp. It seems to me limiting this to some artificial number is by it's very nature going against keeping your body healthy and your mind sharp for a long healthy life. When the balance of our various types of cholesterol goes wacky from poor diet, lack of exercise, stress or exposure to pollutants, then we have problems. Those are facts proven in the scientific studies I have seen. When I had a heart attack, my cholesterol was 147, exercised 4 times a week but had a poor diet and was taking extra calcium as my family has a history of osteoporosis. My plaque was over 70 percent calcium, NOT cholesterol. That was only 5% of it. It is not uncommon or unusual either.

There are many natural solutions to all of the problems associated with heart disease. Since the placebo or sugar pill is almost as effective as the statin and it has no side affects, why not sell it? We have an incredible body and mind capable of doing amazing things. Yet our current medical system practices more like you'd see from evil dark ages nightmares. From slash and burn cancer treatment to hack and medicate heart treatment. Take your pick. Natural solutions worked fine for many years until it was found there was more money in little metal stents and surgery. It doesn't fix the problem, just makes everyone more money. Chemical IV's like EDTA would clean the arteries. In 1965 a cardiologist found a treatment of simple Chondroitin Sulfate in large enough doses also removed the plaque but also strengthened the arteries which all tested and performed like a 20 year olds. Pictures of 85% blockage clear and clean after three months. Wonder what happened? I think you know...

 [ Reply ]
Mercola
  
Micki
[ Joined on 11/06 ]  [ Posted on May 9, 2008]
3 Points        
   
Novice User
  Mercola

Calcium build up in arteries is HIGHLY correlated w/insufficient vitamin K; insufficient K makes calcium deposit incorrectly. Interestingly, K, D and calcium all work together along with magnesium, silicon and some other trace minerals to deposit calcium in bones and teeth (this is an ongoing process that happens all through life, though one wouldn't know this with the way we are all told that our bones deteriorate as we age) and not arteries. The methods of calcium removal that you mention are valid but you should really consider taking K2. Please see "Vitamin K: Beyond Coagulation to Uses in Bone, Vascular, and Anti-Cancer Metabolism" by Lara Pizzorno and Joseph Pizzorno in the Apr/May 2008 Integrative Medicine. This is a truly "wow" article and is a powerful argument for adding D3 and K2 as supplements that can actually be health protective - and it is nearly impossible to meet our needs w/o supplements for several reasons. You have to read these articles and learn the material yourself, as most docs have absolutely NO IDEA that these fat soluble nutrients have such fundamental roles in bones, cardiovascular health, and cancer prevention. Instead, they have been frightened that they are potentially toxic and, when they look up the lame guidelines about adequate intake, they are still ignorant because our IOM is a conflicted agency. Heck, how can any docs know this when they are "educated" by PhRMA??

Mercola
  
Think First
[ Joined on 02/08 ]  [ Posted on May 9, 2008]
       
   
Novice User
  Mercola

I appreciate the info but got restricted by the limit of characters. My blood work did indicate a shortage of Vitamin D and K among others. I have since learned and take D3 along with K2 on a regular basis. Now thanks to taking the Lipitor and Plavix I was prescribed for a period of years before figuring out they were causing a lot more problems than solving, had severely impaired my bodies ability to make COQ10, I have nerve, muscle and memory problems of which I have been able to recover some by taking natural supplements.

I also wanted