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Men with male pattern baldness -- hair loss mainly
affecting the vertex or crown of the head -- face higher risks of heart
attack, chest pain, and coronary artery problems that require surgical
intervention. This risk is especially high in men who also have high blood
pressure or high cholesterol levels. The researchers used data from the
Physicians' Health Study of 22,071 apparently healthy male doctors, aged
40 and older, to evaluate the association of baldness with the risk of
heart disease over an 11-year period.
Increased hair loss was associated with an increasing
risk of coronary heart disease (CHD) events, the authors report. Eleven
years after joining the study, men with male pattern baldness faced the
following increases in CHD risk, compared to men with no hair loss: --
9% with frontal baldness only. -- 23% with mild vertex baldness. -- 32%
with moderate vertex baldness. -- 36% with severe vertex baldness. The
chance of developing heart disease was even higher when the researchers
combined baldness with other risk factors, the investigators note. The
risk of a coronary event increased by 79% when vertex baldness was accompanied
by high blood pressure and nearly tripled when joined by high cholesterol
levels.
A plausible explanation for an association between
baldness and CHD may be elevated androgen (male hormone) levels. Men with
severe baldness appear to have more androgen levels in the scalp, and
higher blood levels of testosterone. High levels of androgens may directly
contribute to both atherosclerosis and thrombosis (arterial blockage due
to a clot), and may adversely influence risk factors such as hypertension
and high cholesterol.
Archives of Internal Medicine
January 24, 2000;160:165-171.
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