Pernicious anemia is a very serious disorder, which
can cause irreversible damage, resulting from a deficiency of vitamin
B12. This study detected H. pylori in 56% of 138 patients with pernicious
anemia. Upon treatment and eradication of the H. pylori infection, there
was significant improvement of B12 status in 40% of the infected patients.
The authors conclude that H. Pylori is a causative factor in many cases
of B12 deficiency and that detection and eradication of it may correct
Arch Intern Med. 2000;160:1349-1353