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Lycopene May Help Prevent Atherosclerosis
Posted by: Dr. Mercola
December 31 2000 | 1,647 views

Low levels of the carotenoid and antioxidant lycopene, found in tomatoes and other red-hued foods may be linked to early atherosclerosis, a new study reports.

Previous research has shown that eating lots of food rich in lycopene (see table below) may reduce the risk of certain diseases including cancer, particularly prostate cancer.

  • Researchers studied 520 middle-aged men and women in southeastern Finland.

  • They used ultrasound imaging to measure the intima-media thickness of the carotid artery, since gradual thickening is a marker for the progression of atherosclerosis.

  • On average, intima-media thickness was greater in men with low levels of lycopene

  • After accounting for all other factors, low lycopene levels were linked to a nearly 18% increase in artery thickness

The researchers suggest that low levels of lycopene may play a role in the development of artery disease.

Atherosclerosis, Thrombosis, and Vascular Biology, December 2000; 20: 2677-2681



Dr. Mercola's Comments:
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There are several important points to note on this research. The first is that the people in this study likely obtained their lycopene from foods and not supplements. It is not known if taking lycopene as a supplement would provide similar benefits.

In general, I am opposed to taking many supplements. I believe that it is far better to consume large amounts of whole foods in the diet program I outline.

It is interesting to note that the lycopene from cooked tomatoes in more bioavailable than raw tomatoes, which is in partial conflict with the principle raw foods are better. However, there are likely some additional beneficial substances, which are lost or destroyed when the tomatoes are cooked. However, by eating lycopene foods with some fat, their availability will be significantly increased as well. It is also likely that people who are on very low-fat diets could have lower levels of lycopene, for this same reason.

It is also important to point out that tomatoes are not "lectin-compatible" for most blood types, if you believe the Eat For Your Blood Type Approach. I am not a huge fan of this system, although I do believe it has some value in fine-tuning one's diet.

The BEST system for determining your ideal foods is the "Listen To Your Body" principle. If YOUR body tells you to avoid eating a food, it is wise to stay away from it. It will generally tell you this in a number of ways. The most common is nausea or digestive disturbances, or a decrease in energy or mental alertness.

Each of us have an individual pattern and if you carefully listen to your body you will be able to find out what your clues are for foods that are not promoting health and wellness in your body.

Below is a table listing the lycopene content of several foods:

Approximate Lycopene Content of Various Foods
Food Lycopene Content
(mg/100g wet weight)
Apricot, dried 0.86
Grapefruit, raw pink 3.36
Guava, fresh 5.40
Guava juice 3.34
Papaya, fresh 2.00-5.30
Tomatoes, fresh 0.88-4.20
Tomatoes, cooked 3.70
Tomato sauce 6.20
Tomato paste 5.40-150.00
Tomato soup, condensed 7.99
Tomato powder, drum or spray dried 112.63-126.49
Tomato juice 5.00-11.60
Sun-dried tomato in oil 46.50
Watermelon, fresh 2.30-7.20
Source: Clinton, -S.K.1998. Lycopene: Chemistry, Biology,
and Implications for human health and disease,
Nutrition Review,56(2)P35-51

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