An international group of reproductive experts plans to launch a serious
effort to clone humans to provide children to infertile couples.
A viable embryo, probably created using stem cells or other cells taken
from an adult, could be available for implantation in the woman's uterus
within 18 months, said Dr. Zavos, an Italian researcher at The Andrology
Institute of America and the Kentucky Center for Reproductive Medicine
and In Vitro Fertilization in Lexington, Kentucky.
Zavos, a 25-year veteran in the reproductive field, hosted a conference
on Thursday in Lexington where he and Italian fertility doctor Severino
Antinori announced plans for the scientific coalition
to clone humans.
"This is going to be the first serious effort," Zavos said
in a telephone interview. "I do know various individual groups that
are acting on their own, but they lack the support."
Scientists have cloned sheep, beginning with "Dolly" in Scotland
in 1997, as well as mice and cows, but any suggestions that human clones
are next have been met by outrage within the scientific community and
in political and religious circles.
"As revolutionary as it may sound, as fictional as it may sound,
it will be done. It's a
genie that is out of the bottle and will be controlled," Zavos said.
He said 10 infertile
couples have volunteered to participate, including an American
pair who cannot conceive because the man's testicles were severed in an
accident.
Zavos said his group would hold a conference in Rome in March, to which
a cardinal from the Vatican would be invited. The Roman Catholic Church
is opposed to human cloning. The consortium would operate in an unnamed
Mediterranean country.
The scientists plan to use regular cells or undifferentiated stem cells
from the husband and insert them into a woman's egg that has been stripped
of its genetic material. The cell would be stimulated to divide and create
an embryo equipped with all the specialty cells that make up a copy of
the man, and then implanted in the wife's uterus.
The wives could also be the ones cloned, depending on the couple's choice,
he said.
"We have a great deal of knowledge. We can grade embryos, we can
do genetic screening, we can do quality control," Zavos said.
"It's not the easiest thing. The stability of the genetic information
is what's important. We're cloning a human being now, we're not trying
to create a Dolly. You don't want to create a monster," he said.
To create animal clones, scientists frequently made hundreds
of failed attempts to develop viable embryos. Medical ethicists
have posed the possibility of cruel failures in human cloning, where genetic
abnormalities result in grotesque fetuses unable to survive outside the
womb.
Antinori has sparked a furor in Italy by helping postmenopausal women
become "granny moms," and has also pioneered a technique to
help sterile men by "cultivating" their nascent sperm cells
inside the testicles of mice.