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For centuries, fatter and more sedentary people have been considered more likely to get diabetes. More recently, many studies have established that obesity and physical inactivity are risk factors for type 2 diabetes mellitus and that weight loss and exercise improve insulin sensitivity and insulin secretion in the short term.
Investigators found that diet and exercise counseling resulted in a 58% reduction in diabetes risk among people who are prime candidates for developing the condition, which is associated with obesity and sedentary lifestyle.
The more lifestyle changes people make, the better. But achieving at least some changes is better than not trying at all. For example, weight loss does not appear to be an absolutely essential part of the equation.
Although even modest weight loss conferred a much lower risk of diabetes, those who participated in four hours of exercise per week -- even if they did not achieve their weight loss goal -- had a reduction in diabetes risk.
After 3 years, a total of 3% of persons per year in the intervention group 6% of people per year in the control group developed diabetes -- a risk reduction of 58% for those in the treatment group.
Changing eating habits and increasing exercise may be daunting, but the study shows that even modest alterations in lifestyle have a clear benefit.
It is commonly argued that it is difficult to change the lifestyle of obese and sedentary people, but such pessimism may not be justified.
Although the average weight loss in response to the intervention was small (about 10 pounds), the effect of these changes in lifestyle on the incidence of diabetes was substantial. The researchers found a lower incidence of diabetes among persons who achieved more of the goals for changes in lifestyle, regardless of the group to which they had been assigned.
The reasonably low dropout rate in the study also indicates that subjects with impaired glucose tolerance are willing and able to participate in a demanding intervention program if it is made available to them.
Type 2 diabetes occurs when the body loses its sensitivity to insulin, the blood sugar-regulating hormone. When this occurs, blood sugar, or glucose, rises to levels that can, over time
- increase a person's risk of developing heart disease,
- kidney failure,
- nerve damage
- and blindness.
More than 14 million Americans are estimated to have the disease and one third of these cases are believed to be undiagnosed, according to the American Diabetes Association.
The New England Journal of Medicine May 3,2001; 344: 1343-1350, 1390-1392
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