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Vitamin C
is an essential protector of body cells.
A newly published study says the vitamin
can also play a "dual role" and, at times, actually
damages cells' genetic material. Investigators say their findings
could help explain why high-dose vitamin C has so far failed
as an experimental cancer therapy.
The study showed that rancid fat molecules
can react with vitamin C to form products that could potentially
harm DNA, although the reaction of these products with DNA
was not demonstrated in the study.
Hence, it was suggested that vitamin C
can form genotoxins (DNA-damaging agents) from lipid hydroperoxides,
the implication being that vitamin C may enhance mutagenesis
and the risk of cancer.
Previous research has shown vitamin C
can promote DNA damage, but this new research demonstrates
a different avenue the vitamin can take in doing harm.
In the average person, vitamin C may regularly act as both
a cell's friend and foe, making a daily megadose of vitamin
C unlikely to fight illness.
This is a
test tube experiment and here is "little evidence"
that these harmful effects of vitamin C are actually going
on in the body.
What's more, a significant number of studies
have shown vitamin C to either have no
effect or a positive
impact on DNA.
As an antioxidant, vitamin
C helps neutralize cell-damaging free radicals,
which are byproducts of metabolism found throughout the body.
Because of this activity, some scientists have suggested that
high doses of vitamin C might help battle cancer by both protecting
healthy cells from the assaults of cancer treatment and by
fighting tumor cells.
The free radicals that vitamin C normally
combats can damage DNA directly or by converting certain fatty
acids into genotoxins. The researchers found that in the test
tube, vitamin C can also give rise to genotoxins by oxidizing
these fats.
According to the researchers, these findings
suggest it will be particularly important to be on guard for
cell damage among participants in trials using vitamin C as
a cancer combatant.
For healthy people the message echoes
tried-and-true nutrition advice: eat
a balanced diet rich in fruits and vegetables rather
than popping a high-dose vitamin C pill, since the vitamin
is no "magic bullet."
The popularity among health-conscious
Americans for popping vitamin C pills was boosted by Linus
Pauling, a Nobel-prize-winning chemist who advocated large
doses of the vitamin. He routinely took 15 grams daily and
was 93 years old when he died in 1994.
However, a nutrient expert at the institution
named for Pauling, said such large doses of vitamin C have
not been proven to be beneficial in clinical studies. The
Linus Pauling Institute does not currently endorse megadoses
or promote vitamin C in preventing a cold.
They also only recommend taking 200
mg of vitamin C as a healthy body can only absorb
about that much a day and the surplus is carried away with
the urine.Their advice is to eat a healthy diet rich in fruits
and vegetables.
The Institute of Medicine, an arm of the
National Academy of Sciences, recommends that women need 75
milligrams of vitamin C daily and 90 milligrams for men. Smokers
need an additional 35 milligrams. These are levels easily
achieved by a balanced diet.
Science June
15, 2001;292:2083-2086 and Washington
Post June
14, 2001
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