|
It appears that newer types
of antidepressants might relieve the hot flashes of menopause.
The study involved women who
had either survived breast cancer or were concerned about the risk of
using estrogen products for hot flashes.
Hormone replacement therapy
is known to relieve hot flashes, but it is not recommended for women with
a history of breast cancer. There is also evidence that it could raise
a woman's risk of developing breast cancer. But recent, early research
has suggested that some newer antidepressants, like Effexor and Paxil,
might alleviate hot flashes and provide an alternative to hormones.
Mayo Clinic researchers studied
81 women, 4 weeks of treatment with Prozac reduced the frequency and severity
of hot flashes overall,. All of the women had a history of "bothersome"
hot flashes that occurred at least 14 times per week.
It is now apparent that the
newer classes of antidepressants can inhibit hot flashes in patients.
This provides a realistic alternative therapy for patients who do not
wish to receive hormones for fear of cancer issues or other reasons."
However, the
benefits of Prozac in this study were "modest." Hot
flash "scores" -- a measure of hot flash frequency and severity
-- fell 50% among women on
the drug, but they also decreased 36%
on inactive treatment with a placebo.
The trial was designed so that
all women spent 4 weeks on the drug then switched to placebo, or vice
versa.
Side effects included
appetite loss, sleep problems, dizziness and mood changes among
other symptoms, but similar rates were seen with Prozac and the placebo.
Women on the drug had more problems with dry mouth.
Journal
of Clinical Oncology March 15, 2002; 20:1578-1583
|