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Progesterone Reduces Premature Births

The hormone progesterone can help prevent premature births in a large number of high-risk pregnancies.

The study found that 306 women who were injected with 17-alpha-hydroxprogesterone caproate (17P), a derivative of the hormone progesterone, once a week had a reduced risk--by 34 percent--of premature birth, or birth before the 37th week of pregnancy. The risk of pre-term birth prior to 32 weeks was reduced by 42 percent. All of the women, including an additional 153 women who were injected with a placebo, had given birth prematurely in the past--the biggest indication of risk.

African American and non-African American women benefited equally from the treatment.

Progesterone, which is naturally produced by the ovaries, has been prescribed for years to help infertile and menopausal women. Earlier small studies had suggested that 17P therapy could help prevent pre-term birth, but no large trial had ever been conducted.

Researchers had planned to enroll 500 women in the study, however stopped the study short because of the dramatic results of the progesterone.

The number of premature babies born in the United States has reportedly risen 27 percent from 1981 to 2001. One in eight babies were born prematurely in 2001.

Researchers plan to conduct a follow-up study to examine whether 17P, an omega-3 fatty acid or a placebo influences premature birth among women already at risk. Omega-3 deficiency has previously been linked to an increased risk of pre-term births.

Annual meeting of the Society for Maternal-Fetal Medicine February 6, 2003



Dr. Mercola''s Comments Dr. Mercola's Comments:

Even traditional medicine has widely accepted the fact that progesterone deficiency is the most common reason why women miscarry during their first trimester.

Many women do receive natural progesterone to prevent recurrences from happening. Please note that I said natural progesterone--if they were given the synthetic version (progestin), most typically medroxyprogesterone or Provera, it would actually facilitate a miscarriage.

The synthetic progesterone binds much more strongly to the body’s progesterone receptors than the real version does. Once Provera binds to this receptor it actually blocks the real version from binding, thus causing a profound real progesterone deficiency. This is one of the major reasons why birth control pills should be completely avoided once a woman becomes pregnant.

If this information is new to you, I highly recommend reading Dr. John Lee’s book What Your Doctor May Not Tell You About Premenopause to get up to speed.

Many women will use progesterone cream to help normalize their body level, but that is frequently shortsighted and may cause problems in the future.

While I frequently recommend natural progesterone for women, it is rarely in the cream format (see article below) as I have found that after women have been on these creams for a number of years their progesterone level becomes extraordinarily high and then the progesterone stops working altogether.

I have tested hundreds of women who had very elevated levels of progesterone due to using the cream.

Now I typically recommend a sublingual form of progesterone that, from my observations, does not elevate a woman’s progesterone levels. However, I will only use this for women with severe menstrual bleeding, cramping PMS, or if their ovaries have been removed.

This is also a short-term strategy. Normally a woman’s progesterone levels become imbalanced due to estrogen excess that is caused by an imbalance in their adrenal glands. The adrenal glands produce cortisol, which is the main biological modulator for estrogen and progesterone.

So it would make far more sense to treat the cause of the imbalance and normalize cortisol levels. One of the best ways to do that is to normalize insulin levels by consuming an appropriate diet as determined by Metabolic Typing.

Stress also seems to be a crucial player here. Effectively addressing the underlying emotional challenges with non-drug solutions is a central factor in normalizing stress levels. There are many ways you can do this, but in my office we use EFT. If you would like in-depth instruction on how to perform this technique, consider my EFT Series on DVD or VHS.

Related Articles:

Progesterone Cream Potential Dangers and Complications

Newer Ways to Use Natural Progesterone--Better Options Than Depo-Provera





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