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Gastric bypass surgery, which helps people to lose large amounts of weight by reducing the absorption of calories, may also result in loss of bone mass, according to a study.
In the surgery, doctors staple off a section of the stomach so that it can only hold a small amount of food and add a bypass that allows food to go around part of the small intestine, limiting the absorption of calories.
The study involved 27 patients who had the Roux-en-Y gastric bypass surgery and another 29 people who were awaiting the procedure. Patients who had had the surgery lost an average of 80 to 100 pounds after 10 months.
However, according to urine and blood tests, they were also breaking down bone faster than it was rebuilt. The more weight lost, the faster the rate of bone breakdown, researchers said.
Patients awaiting surgery were breaking down and rebuilding bone at normal rates. The bone breakdown rate of those who had had the surgery was about twice the rate of those who did not have the surgery.
Researchers are not certain why this effect is occurring, but suggest that the surgery may decrease calcium absorption. Another potential explanation is that the patients’ excess body weight may have been strengthening bones as lifting weights strengthens bones. Therefore, when the excess weight is removed the bones have to adjust to the reduction in weight.
Researchers plan to continue studies to determine whether the findings lead to a loss of bone over time that could put patients at risk of osteoporosis. They note that patients should have their bone density measured every couple of years.
Annual Experimental Biology meeting San Diego April 13, 2003
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