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June 07 2003
Osteoporosis Drug Boniva Approved

 

U.S. regulators approved a new drug, Boniva, for the prevention and treatment of osteoporosis in post-menopausal women. Boniva is being developed by Roche with drug giant GlaxoSmithKline.

The drug’s current formulation requires once-daily dosing. The approval was based on data showing that the bisphosphonate reduced the occurrence of vertebral fractures among post-menopausal women with osteoporosis.

However, similar osteoporosis drugs, such as Merck’s Fosamax, are administered once weekly, which is likely to render Boniva less competitive since it requires daily dosing.

Roche is focusing on clinical trials using less frequent dosing, such as being administered every three to four weeks, and said it is unlikely they will bring the drug to market in its once-daily formulation.

Boniva is also marketed in Europe under the name Bondronat for cancer-related bone complications.

Osteoporosis affects some 10 million people in the United States and close to 34 million more have low bone mass, which makes them more susceptible to the disease.

FDA May 19, 2003



Dr. MercolaDr. Mercola's Comments:

Boniva is a biphosphonate drug not much different than Fosamax. The drug is a metabolic poison that will kill the osteoclast cells in your bone that help create the dynamic balance between bone resorption and bone building.

Bone building is a fine balance of a number of factors. Fosamax is very similar to estrogen's mode of action, but while estrogen inhibits osteoclasts, Fosamax actually KILLS them. Osteoclasts are cells in the bone that actually remove the bone so it can be rebuilt. If these cells are damaged the bone gets much denser. The fallacy in medical thinking, though, is that a denser bone is a stronger bone.

This is just not true. Even though the bones are denser, they are actually weaker because they have not been allowed to remold themselves and readjust to the constantly changing forces that are applied to them. This will actually increase the risk of fracture over time.

Natural progesterone is normally required to stimulate the osteoblasts or the bone rebuilding cells. The synthetic version, or Provera, does not provide this benefit.

The optimal solution to build stronger bones is to normalize the adrenal glands through a variety of techniques. If a woman still has ovaries they can normally be encouraged to produce appropriate amounts of estrogens and progesterone to build strong bones.

The important tools for normalizing the adrenal glands include:

  • An optimal diet
  • Getting to bed by 9 p.m. or 10 p.m.
  • Having a mechanism for coping with the stress in your life, such as EFT
  • Getting one hour of sunlight outside each day (not through glass windows)

As researchers suggested as far back as 1968, the minerals in your bone serve as a buffer against all the acid foods you eat. After a lifetime of buffering the acid load from eating diets that are full of grains, this leads to the gradual loss of minerals in the bones and secondary bone loss. It was suggested that:

"The therapy of osteoporosis may lie in its prevention ... it might be worthwhile to consider decreasing the rate of bone attrition by the use of a diet favoring 'alkaline ash.' This type of diet would emphasize the ingestion of vegetables, fruits, vegetable and protein."

Two nutrients that may have the necessary buffering effects are potassium and magnesium. They are found in a variety of whole, unrefined foods, including vegetables and fruits. Diets high in vegetables and fruits produce a more alkaline urine by contributing a variety of compounds that accept hydrogen ions during their metabolism.

These researchers showed almost 40 years ago that there is a significant and important link between bone density and consumption of potassium and magnesium in the form of vegetables and fruits.

There are theoretical reasons to expect a link between bone and potassium and magnesium. For instance, metabolic balance studies have shown that potassium helps your kidney retain calcium, whereas low potassium intake leads to increasing losses of calcium in your urine.

The bottom line is: it is important to increase your consumption of vegetables if you have low bone density. One of the best ways to do that and normalize high body acid levels is with vegetable juice. Vegetable juice is also high in vitamin K (phylloquinone) that will actually cement the calcium into your bone matrix.

Vitamin K is commonly found in dark green leafy vegetables like collard greens and spinach and is found in its highest concentrations in fermented foods like natto, a fermented soy product. However, most people do not consume enough of these foods to ensure adequate amounts of vitamin K.

Because vitamin K is absolutely essential to build strong bones and prevent heart disease, but it is "the forgotten vitamin" that many people do not get nearly enough of on a daily basis through the foods they eat, I now offer you high-quality vitamin K at a very affordable price.

Aside from improving your bone health, vitamin K plays a significant role in assisting normal blood clotting, and is in fact one of the most important nutritional factors in preventing hardening of the arteries.

Related Articles:

Fosamax May Damage Liver

Fosamax Increases Ulcer Risk Especially if Taken With Anti-Inflammatories

Premarin Fails to Benefit Bones, So Let's Use Fosamax Instead

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