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| Sleep
apnea can make breathing stop for up to a minute |
An antidepressant called mirtazapine may help people with
a potentially life-threatening sleep disorder, sleep apnea,
and may also help heavy snorers.
With sleep apnea, airflow from the nose and mouth to the
lungs is restricted during sleep, causing the person to stop
breathing for up to one minute, sometimes hundreds of times
a night.
Sleep apnea affects an estimated 15 million to 20 million
people in the United States and is associated with an increased
risk of high blood pressure, heart attack, stroke and adult-onset
diabetes.
Additionally, apnea, which means "without breath,"
can lead to behavioral problems and learning difficulties
because people do not get enough rest.
Currently, sleep apnea is treated with mechanical devices
such as masks or nasal prongs, which maintain a continuous
positive airway pressure. However, the devices can be uncomfortable
and difficult to use long-term.
But now researchers have found that mirtazapine, an antidepressant,
can significantly reduce the symptoms of sleep apnea and may
also help heavy snorers.
The study involved 12 people between the ages of 20 and 70
years and was funded by NV Organon, which markets the drug
as Remeron for a treatment for depression.
During three seven-day treatment periods, participants were
given either mirtazapine or a dummy pill one hour before bedtime.
The participants were then monitored throughout the night.
Researchers found that using the drug cut the number of times
breathing stopped or slowed during sleep in half and reduced
the number of times sleep was disrupted by 28 percent.
According to researchers, since the drug helped sleep apnea,
it could also help snoring. However, they questioned whether
snorers would want to take the drug.
The U.S. Food and Drug Adminstration has not approved Mirtazapine
for the treatment of sleep apnea. Its use in this trial was
approved for experimental purposes only.
BBC
News June 4, 2003
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