Researchers have linked vitamin D concentrations greater than 40
nmol/L with improved lower extremity function in ambulatory patients
age 60 and older, regardless of calcium intake, activity level,
sex, age, race or ethnicity.
In the past, vitamin D has been shown to maintain calcium homeostasis
and improve bone density, lowering the risk of fractures. Results
of this published survey suggest vitamin D bolsters muscle strength
and function, therefore decreasing the chance for falls that may
lead to fractures.
Researchers examined the relationship between vitamin D levels
and muscles strength and function in 4,100 subjects, about half
men and half women, age 60 and older, with the mean age being about
71.
Vitamin D -- also known as 25-hydroxyvitamin D or 25(OH)D -- concentrations
were measured in all participants, who were then classified into
five groups, or quintiles, according to their vitamin D level. Participants
also were classified by activity level. About 75 percent of them
were active, meaning they had walked one mile without stopping,
swam, jogged, bicycled, danced, exercised or gardened in the previous
month. Those that had not, about one in four, were considered inactive.
Researchers also controlled for calcium intake, sex, age, race or
ethnicity.
Using a timed 8-foot walk test and a repeated sit-to-stand test,
investigators assessed each subject's lower extremity functionality.
Those who performed the tests in a shorter amount of time were judged
as having better muscle strength and functionality.
Subjects in the highest quintile of vitamin D concentration had
a mean 5 percent decrease in time of 0.27 second in the 8-foot walk
test compared to those in the lowest quintile. For the sit-to-stand
test the highest quintile of participants had a mean 3.9 percent
decrease of 0.67 seconds compared to the lowest group.
Therefore, researchers associated higher vitamin D concentration
with improved lower extremity function. The best results were seen
in subjects with levels from 22.5 to 40 nmol/L. Positive results
were also seen in the 40-90 nmol/L range.
Researchers summarized that in both active and inactive subjects,
those with higher concentrations have better musculoskeletal function.
They noted that while concentrations of 40 nmol/L or greater are
desirable for optimal function, concentrations as high as 100 nmol/L
appear advantageous.
They went on to conclude that vitamin D supplementation may offer
a way to improve lower-extremity function in both active and inactive
elderly subjects.
American
Journal of Clinical Nutrition September 2004 80(3):752-758
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