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October 30 2004
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Iron Imbalance Linked to Parkinson's

 

Each year, more than 1 million Americans suffer from Parkinson’s disease, a degenerative condition affecting movement and balance.

The chances of developing this disease increases with dietary iron imbalances, which negatively affect healthy cells, spurring a reaction of cellular events in the brain. Although too little iron can pose a problem, too much iron is a much bigger concern.

Researchers conducted experiments where mice were fed varying amounts of iron. This was done in order to discover the levels that triggered or sped up symptoms linked to Parkinson’s disease, such as tremors and balance problems. High levels of iron not only prompted Parkinson’s-like symptoms in healthy mice, but also led to the decline and death in those mice already diagnosed with the disease.

However, when researchers tested low levels of iron on the mice they discovered mixed results. Although low levels delayed the onset and slowed progress of the disease in high risk and infected mice, healthy mice experienced reverse effects.

It seemed that iron deficiencies in healthy mice led to decreasing levels of dopamine, a neurotransmitter crucial to relaying brain messages that help control movement and balance. Researchers concluded that iron deficiency, as well as toxicity, lead to dopamine shortages, which in turn are responsible for the onset of Parkinson’s disease.

Some natural dietary sources containing iron include:

  • Red meats
  • Dried fruits
  • Dark leafy greens
  • Tofu
  • Cooked dried beans
  • Wheat germ

EurekAlert October 12, 2004



Dr. Mercola Dr. Mercola's Comments:

If you have had a problem with either too much or too little iron, I recommend getting into the habit of measuring your iron levels on a regular basis.

Generally, most men have too much iron, while most women don’t have enough.

The reason most men have a problem with too much iron is because iron is not readily excreted through the body's usual excretory routes of urine, bile and sweat; rather, the primary way in which iron is lost is through the shedding of cells from the skin or gastrointestinal tract or through blood loss, as in menstrual blood loss or chronic or acute hemorrhage.

After a woman stops menstruating it becomes very important to monitor for excess iron levels, as processed foods that are fortified with iron and any multivitamins with iron will tend to contribute to iron overload.

When excess iron is present, the body’s normal antibacterial mechanisms become severely compromised. Excess iron can also create massive amounts of free radicals.

If your levels are too high – above 100 – it is very important that you donate your blood. The higher your level the more frequently you should donate your blood. If it is from 100 - 150, once every six months should work fine. If it is more than 300, you will want to donate at least every two months and possibly more frequently if you can tolerate it. Donating your blood is an amazingly effective and inexpensive solution for this problem. If for some reason the blood donor center is unable to accept your blood for donation you can obtain a prescription for therapeutic phlebotomy.

If your ferritin level is above 250 you will want to consider taking IP6 or phytic acid when you eat red meat as this will help bind the iron and prevent you from absorbing it.

On the other hand, if your iron levels are 15 or even 20, you can consider iron replacement. The best form of iron replacement would be healthy red meat.

However, if you are a person who eats a steak and it sits like a brick in your stomach, then take this as a clue that you are not likely to tolerate red meat very well, probably because of your nutritional type, and you should likely take an iron replacement.

Thus, whether you are dealing with high or low iron levels, it is always important to measure your levels, as it is key to achieve optimal health.

The best way to determine your iron levels is through a measure of serum ferritin level in conjunction with total iron binding level. Not only is this an inexpensive solution, but also it doesn't require any prescription.

Related Articles:

High Iron & Manganese Linked to Parkinson's

Excess Iron Contributes to Parkinson's Disease

Most People Get Too Much Not Too Little Iron

Excess Iron Damages Blood Vessels

How to Diagnose Iron Overload

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