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October 02 2007
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Not Again! More Diabetes Drug Dangers...

Two more studies published in the prominent medical journal JAMA have raised questions about the safety of both Avandia and Actos, two popular diabetes medications.

Earlier this year, a combined analysis of more than 40 studies, published in the New England Journal of Medicine, found that Avandia, made by GlaxoSmithKline, doubled the risks of heart failure and raised the risks of heart attack by 42 percent.

This finding was corroborated by yet another combined analysis by researchers from Wake Forest University. This time they limited the analysis to four long-term studies. Their findings were almost identical, and Dr. Sonal Singh, co-author of the study, said the FDA should consider withdrawing Avandia from the market.

“If you use Avandia to treat patients with type 2 diabetes,” said Singh, “their chance of getting heart failure due to Avandia is one in 30, and their risk of having a heart attack is one in 220. All due to the drug.”

Additionally, a second study by researchers at the Cleveland Clinic, found that Actos, a similar drug made by Takeda, actually lowered the risks of heart attacks, strokes, and death by about 20 percent but, like Avandia, also raised the risks of heart failure.

Journal of the American Medical Association September 12, 2007;298(10):1189-95

New England Journal of Medicine June 14, 2007; 356:2457-2471 (Free Full-Text Study)

New York Times September 12, 2007           

 



Dr. Mercola Dr. Mercola's Comments:

Avandia is a drug that supposedly helps sensitize your body to insulin. When it first came on the market, it was considered a breakthrough medication for blood-sugar control. More than 6 million people have taken the drug in the eight years it has been available.

Mark my word, it is only a matter of time before this drug is pulled from the market. It is shocking that it has yet to be pulled.

However, what is even more shocking is the profound ignorance that exists in the medical community about diabetes. Most conventional physicians are well intentioned, but absolutely unaware of how to easy it is to reverse this disease.

Type 2 diabetes is one of the easiest diseases to treat, yet we have a pandemic in the US with one of every three people having either outright diabetes or pre-diabetes. As I write this, I learned one hour ago that my dear aunt just died from complications of diabetes

I simply could never convince her to commit to the type of exercise program she would need to control her illness. I have another aunt that died from diabetes, and my Dad still struggles with it. Fortunately, my father makes excellent food choices daily, so his diabetes is very well controlled. He may even outlive all of his (younger) siblings, as he exercises about two hours every day, at 79 years old.

I am certain he would have lost the diabetes battle years ago, if it wasn’t for his exercise program. It really is great to have parents that are willing to adopt suggestions from their children. I realize this is unusual, and I am grateful that both my parents apply the knowledge I share with them.

Some doctors and patients are finally getting wise to the dangers of this drug, with sales of Avandia plunging. After years of warning cries from consumer groups about the heart problems caused by Avandia, as well as its possible connection to liver failure, the message may finally be getting through.

In June, the FDA decided to place its strictest “black box” warning label on both Avandia and Actos, but did not go all the way in protecting your health, as a federal advisory panel voted to keep it on the market, despite its risks.

Although the Vioxx debacle is still fresh in the minds of many folks, GlaxoSmithKline is disputing these latest results, just as they did after the first study came out in The New England Journal of Medicine. This is amazing, as their own internal review uncovered a 30 percent climb in the incidence of heart attacks, according to a report submitted to the FDA last year.

Why You NEVER Need These Drugs

Now, why would you choose drugs as the solution for a disease that is virtually 100 percent curable with SIMPLE lifestyle changes?

Eliminating type 2 diabetes, the type that affects over 95 percent of diabetics, is not rocket science. However, if you are a diabetic, and don’t fully understand the underlying causes of your disease and how it works, you are putting yourself at greater risk of developing cardiovascular complications. (Unfortunately, a vast majority of doctors are also misinformed, thereby giving out misleading information about proper self-management.)

Conventional medicine still insists on treating diabetes as a disease of blood sugar. Why? Because that’s how they can treat it with drugs. However, type 2 diabetes is not merely a disease of elevated blood sugar. It’s a disease of insulin and leptin (a hormone) signaling. These are deeper roots that CAN be treated and corrected—through diet and exercise.

One in three Americans has either pre-diabetes or diabetes. And yet diabetes can easily be controlled or reversed by:

Most diabetic diets focus on the amounts and types of carbohydrates and fats to be consumed. Unfortunately, the type and amount of protein in the diet has largely been ignored.

It’s true that almost all diabetics should swap out their grain-carbs for other foods, but some people will do well substituting with protein, whereas others are better off eating more vegetable-only carbs.

The simplicity of these lifestyle changes is why I find it so appalling that physicians foolishly advise people to take these absolutely unnecessary drugs. They are abrogating their responsibility as teachers, coaches, and mentors to their patients.

The Bottom Line?

Understand that oral drugs for type 2 diabetes are completely unnecessary if you're willing to make some simple lifestyle changes. If you are currently taking these drugs, please protect your health; find a knowledgeable physician who can help you wean yourself off them.

Pay attention folks. Diabetes takes NO prisoners. It is one SERIOUS disease. Do not take it lightly. Optimize your insulin and leptin levels and you will not only be diabetes free, but you will radically slow down the aging process.


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Community Comments ( 30 )
Comment on this Article
  
  
foxtroter
[ Joined on 09/06 ] [ Posted on September 13, 2007 ]
26 Points        
   
 
Savvy User
So sad when Type II diabetes is both preventable and reversable with lifestyle changes.
 [ Reply ]
Mercola
  
Russ Bianchi
[ Joined on 09/06 ]  [ Posted on September 13, 2007]
15 Points        
   
Savvy User
  Mercola
Indeed, moderate regular low impact exercise (walking) has been proven in huge vetted 10 year studies to REVERSE Type II Diabetes!

Reactive protocols HARM or KILL at much higher rates than preventative protocols.
Mercola
  
Patty D
[ Joined on 06/07 ]  [ Posted on September 14, 2007]
15 Points        
   
Savvy User
  Mercola
NOT AGAIN!!!!  Just when people were beginning to feel safe from the "Mad Dinger".  What on earth is in Russ's comment to earn negative points?  Is  there a problem with the system?  The last 2 days in the moderator's blog, I have given points only to see them disappear by the time the page refreshes after I post.  I know I gave the points because it won't allow me to vote again.  Maybe it's a glitch and not a mad dinger at all?
  
  
qtface
[ Joined on 06/06 ] [ Posted on September 14, 2007 ]
22 Points        
   
 
Apprentice User
Have ryou ead of the chemical that is used to bleach flour? It is called "alloxan". It is used by medical researchers to INDUCE diabetes in lab animals used for research. Why is this drug allowed in the food supply and why is it not mentioned in relation to the climbing numbers of diabetics?
 [ Reply ]
Mercola
  
KathieJamisonCote
[ Joined on 04/07 ]  [ Posted on October 2, 2007]
1 Points        
   
Savvy User
  Mercola

I did not know this about alloxan being used to bleach flour and used in experiments to induce diabetes..........isn't that just interesting?  Thank you qtface.

Gamma Girl - Thanks for that info....can't wait to share it.  

To borrow your words

"Most (if not all) diabetes health professionals admit the explosion of type 2 diabetes cannot be genetic because the rates have increased far too quickly."  

Imagine that?  

  
  
samurai
[ Joined on 04/07 ] [ Posted on September 14, 2007 ]
17 Points        
   
 
Savvy User
Isn't it a lot less expensive to just simply pick up the fruit, and drop the potato chips with the meds?
"Here, take this pill.  That way, while you are killing you, we will kill you too.... oh, and you will pay us handsomely for it!!"
 [ Reply ]
Mercola
  
Ali G.
[ Joined on 09/07 ]  [ Posted on September 14, 2007]
6 Points        
   
This user is BELOW novice level and all their comments need to be reviewed with great caution.
  Mercola
Wow, is it that easy? All we have to do is not eat potato chips and eat fruit and we don't have to worry about getting type II diabetes?
Mercola
  
samurai
[ Joined on 04/07 ]  [ Posted on September 14, 2007]
22 Points        
   
Savvy User
  Mercola
No, it's not that simple.  It's just that when people take pills, so they may continue an unhealful lifestyle as opposed to eating well and being free from drugs, it is exactly what big pharma wants you to do.  Did you want me to list other foods? 
Are you not aware of that?  Don't you see that GSK is making money from Avandia and cannot make money from teaching people to eat well?  That won't pay for the Hummer (the car). 
Mercola
  
Ali G.
[ Joined on 09/07 ]  [ Posted on September 14, 2007]
-29 Points        
   
This user is BELOW novice level and all their comments need to be reviewed with great caution.
  Mercola
It is nice to see that you finally posted a comment with some thought to it. You should have posted this thought in the first place.

I came to this Blog because I heard I could educate myself on these topics. Not to read pointless banter, just so people can get positive points ++++5
Mercola
  
Reesacat
[ Joined on 01/07 ]  [ Posted on September 14, 2007]
21 Points        
   
Savvy User
  Mercola
Ali G, laughter is good medicine.

Mercola
  
Patty D
[ Joined on 06/07 ]  [ Posted on September 15, 2007]
17 Points        
   
Savvy User
  Mercola
Ali, open your eyes and your mind.  There is an enormous amount to learn from this forum.  These people want nothing more than to help others.  They are awesome.  So what if there is some "banter".  And, if people were simply worried about points, several would have quit posting a long time ago because of phantom dingers.  Their desire to spread the message outweighs the pettiness of others.  I hope you stay around and learn.
Mercola
  
KathieJamisonCote
[ Joined on 04/07 ]  [ Posted on October 2, 2007]
1 Points        
   
Savvy User
  Mercola

extremely well said Patty D !!!

Ali G - It's a good community......with information that improves your lives. Welcome.  If you stay around, you'll find there is not only information that is life changing, life-saving and life-enhancing, but there are friendships started, support and kind words for those dealing with more on their plate than should be allowed and yes, some bantering......as for the points, they don't mean a rat's ass to me, I speak what's on my mind and in my heart and draw from life experiences that pertain to the issue at hand.  Peace, Kathie

Mercola
  
Health 1
[ Joined on 03/07 ]  [ Posted on October 2, 2007]
4 Points        
   
Novice User
  Mercola

Absolutely Reescat. We have an administrator at our clinic, whom we love dearly. She goes into laughter as the clinic becomes busier and busier, as the hours of each day go by. Before we know it, the whole reception room and practitioners are roaring with laughter. It is good medicne!!!  Research has proven, that laughter is an immune enhancer.

Blessings

Dr. Trudy

  
  
vince
[ Joined on 09/06 ] [ Posted on September 14, 2007 ]
16 Points        
   
 
Apprentice User
 This is particularly disheartening as several mouths ago at the FDA meeting that allowed  Advandia to stay on the selves  Dr. Graham said a preliminary analysis showed Actos to be the safer drug. He also provided a number to injure for each month this drug remains on the market. Until the medical profession realizes that the first ;best;and only risk free treatment for this ailment is diet and exercise many more people will suffer needlessly.
 Thanks Vince
 [ Reply ]
  
  
labrat
[ Joined on 09/06 ] [ Posted on September 14, 2007 ]
11 Points        
   
 
Savvy User
The rise in the popularity of these drugs were spurred on by the P4P movement and the push to get DMII's HA1C's under 7. Failure of conventional glucose control spurred the need for more ammo in the arsenal. Compliance with P4P performance goals to attain those magical "target" numbers by any means is all that counts.
 [ Reply ]
  
  
Ree
[ Joined on 08/06 ] [ Posted on October 2, 2007 ]
6 Points        
   
 
This user is BELOW novice level and all their comments need to be reviewed with great caution.

There was an interesting program on CNN (yeah I know...) the other night where they were talking about obesity and the resulting health problems. They interviewed an inner city woman who had started a big organic garden, which she was lead to do because her young son had developed all sorts of allergies. She was explaining that it is easier to get drugs and guns in their neigborhood than it is to get a tomato. The neighborhood stores sell lots of booze and cigarettes, chips, sodas, cereals and other processed foods but the people have absolutely no access to fresh fruit or vegetables. They live entirely on fast food and processed food. Is it any wonder there is so much obesity, epidemic health problems, not to mention the social problems resulting from such a poor diet. The sad thing is, these people have no choice in the matter. And if they suddenly should have access to fresh wholesome food, they don't know what to do with it. One of the children who came out of the store with 2 bags of chips, when asked about tomatoes said, "ugh, tomatoes are nasty."

This in my opinion is a form of genocide.

 [ Reply ]
Mercola