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October 25 2007
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Could You Live Longer Than 140 Years?

Cambridge researcher Aubrey de Grey – featured in this video -- believes aging is a preventable phenomenon, much like a disease, stating that aging is merely a side effect of being alive.

Here he explains his belief that humans could live for centuries, if only we approach the aging process as “an engineering problem.”

He outlines the seven basic ways people age, and how to solve each one. And if we get to work now, he says, humans alive today could live to be 1,000.

According to de Grey, these “7 Deadly Things” are responsible for your physical aging, and are the basis of his “engineering approach” solutions:

  • Cell loss/atrophy

  • Death-resistant cells

  • Nuclear mutations and epimutations

  • mtDNA (mitochondrial DNA) mutations

  • Protein cross links

  • Junk inside cells

  • Junk outside cells

Essentially, de Grey’s hypothesis states that if you can keep these seven deadly cell-damaging processes below the threshold of pathology – the state where processes start to break cells down until your body dies from the cumulative damage – you will be able to extend your life indefinitely.

In other anti-aging news, published in Best Life magazine, two preeminent aging experts have placed a bet on whether or not someone living today will be alive in 2150.

Steven Austad, biologist and professor of cellular and structural biology at the Sam and Ann Barshop Institute for Longevity and Aging Studies, believes someone alive today will still be alive in 2150. For the past 20 years, Austad has researched the fundamentals of aging, and has been able to drastically extend the lifespan of various animals by tinkering with their genes, or restricting their calorie intake.

Jay Olshansky, on the other hand, believes there are too many hurdles to be overcome, suspecting any benefit derived from anti-aging drugs will probably be wiped out by rising threats to public health, such as obesity and diabetes. In fact, the demographic models Olshansky and his colleagues have built project that obesity alone will cut the life expectancy of Americans by two to five years within the next 50 years.

Both experts agree, however, that science is making radical advances. Scientists now have a much more detailed understanding of how shutting down certain genes and restricting calories slow your aging process.

The shared factor between all long-lived animals is their superior capability to repair their DNA.

Edward Masoro, at the University of Texas, pioneered research in the 1990’s, showing that a low-calorie diet switches on a key gene called SIRT1 that controls a network of other genes, which in turn create proteins that protect cells from damage. The idea proposed by more than a dozen pharmaceutical companies working on anti-aging drugs, is that you may one day be able to simply take a pill that switches on SIRT1 in your cells.

One such molecule is resveratrol, produced by grapes and other plants. Sirtis Pharmaceuticals, Elixir Pharmaceutical, and about a dozen others are pursuing these kinds of molecular-based anti-aging drugs.

The current old-age record holder is Jeanne Calment, a Frenchwoman who died in 1997 at the age of 122, after smoking for nearly 100 years.

Best Life September 22, 2007

(Watch this video: 22 minutes, 55 seconds)



Dr. MercolaDr. Mercola's Comments:

You probably don’t realize it, but Aubrey De Grey is one of the leading anti aging researchers in the world. This lecture he gave at TED is a major treat and will give you insights into what the top thinking in the world is on this subject.

Centenarians, people who live to be 100 years or older, are actually becoming more and more common in the United States. In 1950, there were 2,300 U.S. centenarians and by 2003, there were more than 40,000.

It does not seem unrealistic that in the not too distant future, science will be able to add one year of longevity per year, so the AVERAGE life expectancy could be over 100 years in the next 30 years or so. I believe the current maximum lifespan is about 120 years and any manipulation of genes is unlikely to improve your lifespan significantly beyond that. However the more I study this area, the more I am absolutely convinced that Professor De Grey is absolutely correct, and it is not unrealistic to extend the human lifespan well beyond 120 years old.

Ironically, even though most people express an interest in living to their maximum potential, many people refuse to use the available methods that are sure to slow aging. If they did, we would surely not be facing the ever-increasing epidemics of obesity and diabetes in the United States.

Unfortunately, drug companies are aware of this fact as well and are rapidly jumping on the bandwagon to develop highly unnatural analogs, which they can patent and use to make a handsome profit. You can be virtually guaranteed that these synthetic versions will be grossly inferior to the real deal, especially when it comes to side effects and potential toxicity.

Rather than sitting idly by, waiting for another “magic pill” that will erase old age -- with who-knows-what kind of unforeseen and potentially disastrous side effects -- you can take control of your health, and hence increase your lifespan, NOW.

What Can You do NOW to Maximize Your Lifespan?

If you want to take advantage of the advances in this new science you will need to follow healthy lifestyle principles like the ones I outline below. Probably the most important is normalizing your insulin and leptin levels. There is no way you will age slowly with elevated insulin or leptin levels.

  • Keep your insulin levels low -- Elevated insulin levels are one of your key physical influences that contribute to rapid aging, and there is no question that optimizing your insulin levels is an absolute necessity if you want to slow down your aging process. Consuming sugar and grains will increase your insulin level, which is the equivalent of slamming your foot on your aging accelerator. There’s simply no more potent way to accelerate aging than eating sugar and grains.
  • Eat a healthy diet based on your nutritional type – My nutrition plan, based on natural whole foods, is your first step toward increasing your chances of living a longer, healthier life. The heart of my program is the elimination, or at the very least, drastic reduction of grains and sugar in your diet, which is a far simpler way of restricting your calorie intake naturally, without suffering.
  • Take your omega-3 fats – Krill or fish oil is a strong factor in helping people live longer, and many experts believe that it is likely the predominant reason why the Japanese are the longest lived race on the planet.
  • Get your antioxidants from foodsAntioxidants have been shown to have anti-aging effects. Good sources include blueberries, cranberries, blackberries, raspberries, strawberries, cherries, beans, and artichokes.
  • Switch to coconut oil – Another excellent anti-aging food is coconut oil. In fact, it’s doubly beneficial because it can be both eaten and applied directly to your skin. Coconut oil can be used in place of other oils, margarine, butter, or shortening, and can be used for all your cooking needs. It can help you lose weight, or maintain your already good weight, reduce your risk of heart disease, and lower your cholesterol, among other things.
  • Get your resveratrol naturallyResveratrol is one of the forerunners in the anti-aging pill race, but more than likely, by the time they’ve manipulated it into a synthetic pill, it won’t be healthy for you. Although resveratrol is the antioxidant found in red wine, I can’t recommend drinking wine in the hopes of extending your life because alcohol is a neurotoxin that can poison your brain and harm your body’s delicate hormonal balance. Instead, get your resveratrol from natural sources, such as whole grape skins and seeds, raspberries, mulberries, and peanuts.
  • Get plenty of exercise -- Studies repeatedly show that regular, moderate-to-vigorous exercise can help prevent or delay your onset of hypertension, obesity, heart disease, osteoporosis, and the falls that lead to hip fracture. Although a lifetime of regular exercise is ideal, it’s never too late to start. It’s been shown that even individuals in their 70’s can substantially increase both strength and endurance with exercise.
  • Avoid pharmaceutical drugsPharmaceutical drugs kill thousands of people prematurely every year – as an expected side effect of the action of the drug. And, if you adhere to a healthy lifestyle, you most likely will never need any of them in the first place.

There is no quick fix when it comes to life extension – no pill and no magic fountain. While there are certainly some exceptions -- some centenarians do little in the way of healthy eating or exercise -- for most of us, living a healthy life well into our 100’s will take some dedication to making healthy lifestyle changes, and it's up to you to decide if it’s worth it.


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Community Comments ( 52 )
Comment on this Article
  
  
mmc88121
[ Joined on 11/06 ] [ Posted on October 4, 2007 ]
12 Points        
   
 
Moderator User
I have no problem with someone living to the age of 150,  I have a problem with someone living to age 150 and not in the best of health.  I have seen several people over the age of 100 and most of them are intelligent and articulate until the last few weeks of their life.  And most of them have nobody to talk to.

Mary
 [ Reply ]
Mercola
  
Vicki Marie
[ Joined on 06/06 ]  [ Posted on October 5, 2007]
1 Points        
   
Savvy User
  Mercola
I know we discussed living to be over 100 a few months ago. Someone bought up a good point. Would you want to live so long that you watch everyone you love die? I think most of us agreed that quality was more important. Live a healthy life and you will most likely live to a ripe old age before moving on.
Mercola
  
Katee Roux
[ Joined on 07/07 ]  [ Posted on October 5, 2007]
8 Points        
   
Savvy User
  Mercola
As Vicki Marie said, i know this was discussed before & some have said they'll all meet when they hit 140.

For myself, i really don't care how long i live, as long as i am able to LIVE while i'm alive.  Watching some program the other day, they were singing the song, "I want to live til i die," & my father in law said, "That's what we all do, isn't it?"

No, there is living, & there is existing.

Currently, my "quality of life" is very low.  I trust this will get better as i improve & follow the recommendations of Dr. Mercola & others.  Struggling to have the energy to get out of bed, prepare some food, & doing dishes, isn't really living.  

The way we are headed with the current standard American diet & pollution from the air, from all the products used in home & personal care, abuses of pharmaceuticals, from all our daily living, will soon have many in this nation at a point of existance not true life.  We're close to it already, & the "experts" - scientists & docs - aren't helping anything.
Mercola
  
Health 1
[ Joined on 03/07 ]  [ Posted on October 27, 2007]
       
   
Novice User
  Mercola

Well put Katie. Your heightened awareness of what is happening as far as polution on various fronts, resulting in the lack of quality of life, will ultimately help you to regain your health. You are reading the right info right here through Dr. Mercola and many other's input of knowledge and useful much needed info. Implementing and finding the individual biochemical balance which will aid recovery is what's challenging...but you will find it. You have a good grasp of contributing factors, which impair optimal health.

God bless you.

Dr. Trudy

  
  
Phantom O' Banjo
[ Joined on 09/06 ] [ Posted on October 4, 2007 ]
8 Points        
   
 
Savvy User
The Gov will have to up the retirement age to 70!   lol
 [ Reply ]
Mercola
  
foxtroter
[ Joined on 09/06 ]  [ Posted on October 4, 2007]
4 Points        
   
Savvy User
  Mercola
Japan's government is paying for development of robots to take care of their elderly. Not so funny.
Mercola
  
Russ Bianchi
[ Joined on 09/06 ]  [ Posted on October 4, 2007]
4 Points        
   
Savvy User
  Mercola
Not that anyone can even begin to buy a week's worth of groceries off a monthly Social Security check, but please remember Uncle Sam on average only sends out 16 to 18 (depending on the part of the country) SS retirement checks, before the mortality statistics take over.

By upping retirement ages, based off life expectancy tables, in point of fact, Uncle Sam has taken in a life time of withholding, and paid out very little in return to you!

By the continued allowance, via FDA and USDA, of dumbing-down the food, pharma and beverage chains, and subsidizing tobacco, alcohol, firearms for tax revenue, along with gmo agri-business through the annual Farm Bill subsidy, Uncle Sam is hedging his bets, to make sure the money keeps coming in, and as little as possible is returned, to the real earners of that revenue.

I heard a quote the other day that stuck:  "To believe government is the ultimate guarrantor of freedom and prospersity in any nation, and individual or private sector enterprise and ingenuity is the oppressor, is to also believe the 'mirror on the wall' will tell you 'who is the fairest one of all'."

TO YOUR OPTIUM HEALTH, HAPPINESS & PROSPERITY BY TAKING CHARGE OF YOUR OWN LIVES!

;-)

Uncle Russ
Mercola
  
Bridestein
[ Joined on 12/06 ]  [ Posted on October 4, 2007]
3 Points        
   
Savvy User
  Mercola
Phantom - how old are you? I already have to wait until I'm 72.
Mercola
  
Patty D
[ Joined on 06/07 ]  [ Posted on October 5, 2007]
12 Points        
   
Savvy User
  Mercola
I guess I'm going to break Social Security all by myself.  I get disability right now and the way I was going I likely could have met Russ's statistics.  In 5 months I have come far enough and "cured" enough problems with nutrition that I'm believing not only can I live a lot longer, but that I'll actually have a better quality of life than I've seen in many years.  I'm wanting so bad to go back to work and I'm believing it will happen!   Of course, I don't see going back to work as a nurse or in pharmacy as very likely considering my new beliefs :)
Mercola
  
BeyondOrganic
[ Joined on 06/06 ]  [ Posted on October 6, 2007]
2 Points        
   
Savvy User
  Mercola
They're working very had by controlling the population making sure most don't survive to the age of 70.
Mercola
  
MaryAlice
[ Joined on 12/06 ]  [ Posted on October 27, 2007]
       
   
Novice User
  Mercola

How about adding the thought/energy component to the mix here?  Do we age/deteriorate partly because we EXPECT to?  Doctors tell us that is just a fact of life; we have numerous cliche's about aging and deterioration. If we truly create our own reality, then it it in our best interest to begin believing,acting and speaking as though health, happiness and abudance are given to us as rights by our Creator.  Depak Chopra has some amazing writings along this line.  Quantum physics seem to be pointing this way!  What do we have to lose when we put positive energy forward, believing it is possible?  If we all spend our creative time ("work") doing what we love, that energy alone propells us forward in a positve, beneficial light that compounds as it touches others.  The book Power vs. Force is another that sheds some amazing light on this subject.  The positive/enlightened thoughts of one outweighs the not-there-yet thinking of others.  We are reaching a tipping point.  Keep up the intent to improvement and better ways!

  
  
marvinlzinn
[ Joined on 06/06 ] [ Posted on October 27, 2007 ]
6 Points        
   
 
Apprentice User

Hmmm. I must be the opposite of most people.

As a child I had much disease. Over 40 years I learned to stop junk food and eat things as close as I could find to what God created. Then I totally eliminated all disease I used to have. My health is excellent and most people think I will live longer than others.

After an injury a couple years ago (broken head, unconscious seven weeks), I recovered to excellent health when everyone, including doctors expected me dead.

But I have no fear of death, today or tomorrow. Considering the world condition and prospect future, I have no desire to suffer through it. Five years more is quite enough.

I can die any minute, from which I will live forever in a better place.

marvin

 [ Reply ]
Mercola
  
BeyondOrganic
[ Joined on 06/06 ]  [ Posted on October 28, 2007]
1 Points        
   
Savvy User
  Mercola

My dad is in that better place now.  

Mercola
  
Lynn46
[ Joined on 12/06 ]  [ Posted on October 31, 2007]
-1 Points        
   
Savvy User
  Mercola

marvinizinn said, "But I have no fear of death, today or tomorrow. Considering the world condition and prospect future, I have no desire to suffer through it. Five years more is quite enough."

Marvin, you hit the nail "dead on." (Sorry about the pun.) After a life-altering and attitude-altering brush with near-death, I think that your perspective is a realistic, healthy one. I have gone through a different, yet similar, experience as yours. I am content to "go" at any time that my Maker calls me from my Earthly existence. I believe that there is another more satisfying existence in another realm of the Universe. I have no need or desire to "live to 140."

Lynn

  
  
Freedom
[ Joined on 02/07 ] [ Posted on October 27, 2007 ]
5 Points        
   
 
Apprentice User

I expect I this will be amusing to most people but...........my eye pressure was up to 26 and causing concern to my optician; I regulary have 6 monthly glaucoma checks; although never have had and do not have this.

So..........me being me after reading about how a mental attitude towards health may be beneficial, decided to concentrate my thoughts on the Canal of Schlem; this is the minute vent that allows the eye to release pressure and so maintain a working eye pressure and in turn stops an