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November 13 2007
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Mouse Studies Confirm the Key to Longevity

Mice lacking the insulin receptor substrate are more resistant to aging than normal mice, according to University College London researchers.

The finding further confirms the link between insulin signaling pathways and aging, and may have implications on aging in humans.

In the study, mice were engineered to lack either insulin receptor substrate IRS-1 or IRS-2, both proteins that are activated by the hormone insulin, which regulates glucose and fat metabolism. Compared with normal mice, the mice lacking IRS-1 had:

  • A 20 percent increase in their average lifespan (30 percent for female mice)

  • Better health as they aged
In contrast, mice lacking IRS-2 had shorter lives than normal mice, and developed signs of obesity and type 2 diabetes. 

Sources:



Dr. Mercola Dr. Mercola's Comments:
It is now a well-known fact that insulin speeds up aging. Eating sugar and grains will increase your insulin level, and that is the equivalent of slamming your foot on your aging accelerator. Folks, there are only a few other ways to accelerate aging faster than eating sugar and grains.

However, insulin may not be the most important hormone when it comes to chronic diseases that are typically associated with the aging process.

Relatively recent research has uncovered that leptin -- a hormone produced by fat that tells your body whether it needs more energy (and thereby controls your appetite) and what to do with the energy it does have -- may get the top billing.

The above study lends more evidence to the importance of the signaling pathways of your hormones. This is an intricate system that needs to be kept precisely balanced so that your body can function properly.

Leptin, for instance, largely influences, if not controls, the functions of the hypothalamus in your brain, which impacts your:
  • Reproduction
  • Thyroid function
  • Adrenal function
  • Sympathetic nervous system
Like your insulin levels, if your leptin levels become elevated, your body systems will develop a resistance to this hormone, which will wreak havoc in your body.

Ron Rosedale, MD, who is one of the leading experts on leptin and the author of The Rosedale Diet, does an excellent job of explaining what happens when your leptin signaling runs amok:

“As the appetite control centers in your hypothalamus become leptin-resistant and cannot hear the message from leptin to curb hunger and stop storing fat, it believes that you do not have enough fat stores to live through a potential famine and you must eat more and make more fat.

Also lost is the knowledge of where to put that fat, and there is a preponderance stored in your abdomen, including your abdominal organs such as your liver, disrupting your liver's ability to listen to other signals such as those from insulin. This causes your liver to manufacture too much sugar from protein contributing to diabetes, and contributes importantly to the breakdown of your muscle and bone causing weakness and osteoporosis.

The communication and knowledge of where to put calcium is also disrupted. Calcium is deposited in your blood vessels instead of your bone, which contributes to osteoporosis while calcifying and hardening your arteries.”

These disruptions have been linked to many of the diseases of “aging,” including:
  • Diabetes
  • Elevated blood pressure
  • Increases in blood coagulation
  • Heart disease
  • Increased inflammation
What can you do to increase your own longevity and keep your hormones in balance? You can start that process by dipping into that "fountain of youth" already available to you: eating a healthy diet.

The other variable that may be even more of an influence on your lifespan than even insulin and leptin is your emotional health. Emotional trauma, and particularly negative emotions that stay with you for long periods of time, will accelerate aging, plain and simple.

My full plan for longevity is detailed in Take Control of Your Health, but the 10 steps that all of you can start working on right now to enjoy a happier, healthier, longer life are as follows:
  1. Have your emotional traumas addressed (try using an energy psychology process such as the psychological acupressure in Emotional Freedom Technique (EFT) to do this)

  2. Get enough sunlight exposure to safely optimize your vitamin D levels, and have good options which contain vitamin D, such as cod liver oil, in the winter months.

  3. Drink pure water

  4. Avoid toxins

  5. Eat the right fats

  6. Eat right for your Nutritional Type

  7. Eat raw foods

  8. Control your insulin and leptin levels

  9. Exercise

  10. Sleep properly

Related Articles:

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Community Comments ( 28 )
Comment on this Article
  
  
"David"
[ Joined on 08/06 ] [ Posted on October 25, 2007 ]
21 Points        
   
 
Savvy User
As a result of these findings, all mice are to stop taking sugar in their tea and will henceforth only consume artificial sweetners...and HFCS, of course, in order to prevent the premature proliference of crochety, grey haired mice;)
 [ Reply ]
Mercola
  
Russ Bianchi
[ Joined on 09/06 ]  [ Posted on October 25, 2007]
12 Points        
   
Savvy User
  Mercola
On Behalf Of Mighty Mouse, Mickey Mouse, Minnie Mouse, Jerry the Mouse, Chuck E. Cheese, Church Mice, Sneezer the Mouse, Steward Little, The 3 Blind Mice, Steinbeckian Mice, The Elephants Love Mice Association,  Pied Piper & Hamelin Enterprises, Lab Rats & White Coats Anonymous,  All Hand Held Electronic Or Mechanical Computer Enabling Devices, Mouseketeers & The House of Mouse, Aesopian Mice, and Mouseanistas Everywhere:

"Hand Over The Organic Raw Cheese & No One Gets Hurt!"

;-)

Uncle Russ
Mercola
  
Bridestein
[ Joined on 12/06 ]  [ Posted on October 25, 2007]
7 Points        
   
Savvy User
  Mercola
Russ - you forgot Speedy Gonzales ;-)
Oooh, and what about Miss Bianca and Bernard?
Mercola
  
Russ Bianchi
[ Joined on 09/06 ]  [ Posted on October 25, 2007]
6 Points        
   
Savvy User
  Mercola
How could I forget Senior Speedy?! 

I feel like some "Cheese....and Speedy is a friend of evreebodiees seeester!" 
Mercola
  
JJReed
[ Joined on 06/06 ]  [ Posted on October 26, 2007]
4 Points        
   
Apprentice User
  Mercola
Implications for the prevalence of diabetes? My 20-yr old son just read me the scary statistic that about 65% of his college classmates are affected by diabetes to a greater or lesser degree. These are mostly otherwise "healthy" young adults.
 
This is at a very intense entertainment industry school (computer design, animation, gaming, film, music, etc) where students stay in labs sometimes 2-3 days at a time to complete projects.  Healthier food in vending machines (ban the soda and candy they're living on)!? Maybe I should hook them up with Dr. Mercola for Whey Protein Shakes and Cocoa Casava bars and watch those numbers drastically decline. Hmmm....
Mercola
  
LoriSm
[ Joined on 08/07 ]  [ Posted on November 13, 2007]
       
   
Novice User
  Mercola

Russ and David,

Thanks for the laugh!!! You both have a great sense of humor!

Lori

  
  
foxtroter
[ Joined on 09/06 ] [ Posted on October 25, 2007 ]
15 Points        
   
 
Savvy User
When are they going to put warning labels on soda cans in the same way they do on cigarette packages?
 [ Reply ]
Mercola
  
Russ Bianchi
[ Joined on 09/06 ]  [ Posted on October 25, 2007]
       
   
Savvy User
  Mercola
Not in your or my life time, the HFCS will have killed those stupid enough to drink this soda poison anyway...
Mercola
  
Katee Roux
[ Joined on 07/07 ]  [ Posted on October 26, 2007]
       
   
Savvy User
  Mercola
I don't know, Russ.  About 7 years ago i read that a scientist believed the two biggest dangers (his choice not mine, i'd include GM/GE) were transfats & HFCS. 

The public is now being made aware of transfats, even tho they are still in some items, & the food industry is playing hard & fast with reporting them ("0 grams transfats").  Still, more folks are aware of this than ever before. 

Maybe, with a push, it will happen with HFCS, as well.
Mercola
  
katz
[ Joined on 11/06 ]  [ Posted on October 29, 2007]
       
   
Apprentice User
  Mercola
Yes , they need to put label's on  both the regular and diet soda's !
WHY, do the kid's need to stuff  on junk in school anyway ? Why don't school's ban the vending machines because of the $$. I never was allowed to eat or drink in school and I was able to learn and survive , If they must eat something maby, have some health type in the vending machines and don't allow teachers a fridge in their room with sodas and candy for sale to the kid's , Fat up's the Insulin and most of us could stand to loose some fat, I know I could and I don't drink soda's.
  
  
mmc88121
[ Joined on 11/06 ] [ Posted on October 25, 2007 ]
7 Points        
   
 
Moderator User
Do humans have the same insulin receptors and do they function the same way in humans.  I would like the answer to those questions also.  The only way they would eliminate HFCS from processed foods is if they found something that would be even less costly and more addictive.

Mary
 [ Reply ]
  
  
seg
[ Joined on 11/06 ] [ Posted on October 26, 2007 ]
5 Points        
   
 
Savvy User
A big hurray to Ron Rosedale !!!!!!!... He and others been saying this for eons but only a few actual listens.....I imagine one day when it's officially confirmed the PRIZE  would go to some newby scientist who would have been in diapers since Ron's discovery.... Nontheless it's welcome news for us...
 [ Reply ]
  
  
HaloTeK
[ Joined on 01/07 ] [ Posted on October 27, 2007 ]
3 Points        
   
 
Novice User
OK- insulin has potent aging implications.   But why hasn't there been more research into the most potent macronutrient ratios for optimal longevity.  Too much protein seems to speed aging outside of any insulin response.  So we need to optimize fat and carbohydrate ratios!
 [ Reply ]
  
  
TonyD
[ Joined on 06/06 ] [ Posted on November 13, 2007 ]
1 Points        
   
 
Novice User

How about R-Lipoic Acid to extend life?

"But now have a look at the results in the animals who were given access to a diet enriched in R(+)-Lipoic Acid. Here, the results were undeniable. The longest-lived animals in this group lived dramatically longer lives than those in anyother cohort. In fact, the mice with supplemental R(+)-Lipoic Acid in their diets exceeded, by a wide margin, the maximum lifespan of animals left to live out their normal lives (Figure 9 ). Animals in the other groups averaged a maximum lifespan of 36 weeks (26 weeks from the beginning of the study), versus a maximum lifespan of 48 weeks for the R(+)-Lipoic Acid group!"

www.ralapure.com/.../06e.asp

 [ Reply ]
  
  
gj2567696
[ Joined on 06/06 ] [ Posted on November 13, 2007 ]
1 Points        
   
 
Novice User

I didn't see anything in regards to RNA on your site, but I read that having enough RNA is the single most important factor in how long you live. If you eat an abundant amount of RNA, you will get younger. Unfortunately I am currently living in China and can't find a single can of Sardines amazingly enough. Not even in the huge Wallmart stores here in Chongqing.

There are other factors too such as eating a diet that is too acid consistently. I have a theory that part of the problem with diabetes is the acid/alkaline balance. If the pancreas gets too acid, it ceases to repair itself and shuts down. Since I stopped overloading myself with acidic foods, I found it much easier to control my diabetes with a careful diet. I have found no probiotics here, but I can now consume unsweetened yogurt which I could not eat before. I do not do well on the sweetened stuff, but again this is probably because the added sugar brings the pH down into the acid range as well as increasing the insulin response. What I try to do is make my dinner the most alkaline because my lunch usually has a high meat content. So my dinner which is usually consumed at work is a couple of plain yogurts and some almonds. Since almonds are high in fiber, they fill me up quickly without having to eat a huge bag. I get home in the evening usually around 9:30 pm and snack on a meihoutou (Kiwi Fruit) and some pumpkin seeds.

Pumpkin seeds and Almonds are both high in magnesium and zinc as well as other trace minerals. I do take some supplements here as well.

On the flip side I may or may not be harming myself eating Pecans in the evening at times, but they are one of the healthiest nuts you can eat. As a bonus they have a generous amount of L-Arginine which is good for your heart, and sex drive. Although they are acidic, they have plenty of EFA's as well and fill you up quickly.

I eat a couple of sunnyside up eggs along with some fresh (uncooked) onion slices and a couple of walnuts for breakfast.

 [ Reply ]
  
  
Mystral
[ Joined on 11/07 ] [ Posted on November 13, 2007 ]
1 Points        
   
 
Novice User

Have been lurking for (seemingly) years.  Always enjoy the discussions and the good chuckle that many of the posts bring.   Right.  Aging - well, me for one would *hate to live to a vast old age.  Why?  Simple. Finances!  What would be the point of living in utter penury, no quality of life, most probably in one of those institutionalised 'age' state-run housing benefit regimes...being regimented by 'bossy staff'.  Not me.

But, with sufficient funds, then another story - but unless I win the jack-pot of summat or the other it is gonna be the state pension which will not even pay the UK poll tax let alone feed and clothe me, AND provide heating!  I scrimp and save as it is and dare not turn on the CH - yet.  So, headwarmers (woolley hat), thermals, heavy socks and etc etc.  Not much fun.  Add in being riddled with arthritis and diagnosed with ankylosing spondylitis (inflammatory spine disease + ALL the attendant AS problems) who would want to live to a real ripe old age?  Again.  Not me!

Now as for the rest.  We Brits do not eat 'spotted ***' - that went out with the 1950s 'school dinners' - and was certainly never served in my parent's home (knew their nutrition and knew better - haha).  As for 'boiled pies' - *where did that one come from?  Haggis is boiled, but it aint a pie.  So am confused as to where? <LOL>

As for sodas - not in this house.  Once tried coca-cola when I lived and worked in India: lots of ice cubes (yuck) so then a full fresh lime squeezed into it (still yuck) and haven't wanted to try it again - won't have it in the house, but am advised that it is quite good for cleaning lavatories?

Read ALL the labels and basically eat reasonably healthy - no sugar (don't like sugar) as for chocolate, horrible.  Fats?  No, but have 'proper' butter.  Meat, and red meat in particular?  Very little, don't go too well with autoimmune problems!  And so on and so forth.  I aint healthy, not with AS, but do pretty good for a 70yr old <VBG>

Mystral

 [ Reply ]
  
  
jae
[ Joined on 12/06 ] [ Posted on November 14, 2007 ]
       
   
 
This user is BELOW novice level and all their comments need to be reviewed with great caution.

i remember reading a journal article when i was in college entiltled "Soft Drinks Do Not Cause Obesity in Children" and in miniscule letters at the very bottom it said "This study was funded by the Coca-Cola Company". I just found that humorous.

 [ Reply ]
  
  
VitaGuy
[ Joined on 06/06 ] [ Posted on November 13, 2007 ]