Insulin resistance is common in patients with metabolic disorders and is found in the vast majority of those with multiple metabolic disorders. The researchers found insulin resistance in the following percentage of patients:
- 66% in subjects with impaired glucose tolerance,
- 84% in those with noninsulin dependent diabetes mellitus (NIDDM),
- 54% in participants with hypercholesterolemia,
- 84% in those with hypertriglyceridemia,
- 88% in subjects with low high-density lipoprotein (HDL) cholesterol levels,
- 63% in participants with hyperuricemia and
- 58% in those with hypertension.
In individuals with combined metabolic disorders, nearly all demonstrated insulin resistance, the researchers say. In particular, hypertriglyceridemia and low HDL cholesterol almost never occurred as isolated disorders, and were nearly always associated with insulin resistance.
On the other hand, insulin resistance was not significantly more common in patients with isolated hypercholesterolemia, hyperuricemia, or hypertension than in the study population as a whole, in which the prevalence was approximately 45%. Nearly 10% of subjects demonstrated insulin resistance in the absence of any metabolic disorder.
Diabetes October, 1998;47:1643-1649.
Dr. Mercola's Comment:
This is a wonderful new study that confirms some of the most important work that I do. I find it fascinating that they found that if one had a combination of the problems listed above nearly 100% of the persons had insulin resistance.
The researchers did not include the one variable that is present in one out of three people in this country: elevated weight. If you have a combination of any two of these conditions, you can be virtually guaranteed that you need to reduce your grain carbohydrates.
The best simple resource for that is the Heller book Carbohydrate Addict Diet Lifespan Program. The caution, however, is to not use the reward meal they recommend until the metabolic problem one is treating is reversed.