Anti-Inflammatory Drugs (NSAIDS) Reduce Effectiveness of Antihypertensive Therapy

January 02, 2008 | 3,355 views

Although evidence of a link between the use of nonsteroidal antiinflammatory drugs (NSAIDs) and elevated blood pressure (BP) has been inconsistent, an analysis finds that the drugs are associated with a clinically important increase in BP. The effect is most pronounced in patients on antihypertensive therapy

Pooled data drawn from published reports of randomized trials of younger adults reveal that NSAID usage produces a clinically significant increment in mean blood pressure of approximately 5 mm Hg. When sustained over several years of NSAID use, this elevation could be associated with a substantial increase in the risk of stroke and coronary heart disease events.

Drug Safety November, 1997;17:277-289

COMMENT: Not only do these NSAIDs kill 30,000 people every year due to bleeding ulcers, they can also cause kidney damage which will raise your blood pressure. Clearly, they are useful agents in some cases. However, one needs to use them very cautiously. It is always better to attempt to treat the cause of the illness rather than the symptoms. Some of the most common reasons people take these drugs would be for degenerative arthritis. Supplements like glucosamine and chondroitin sulfates are much safer and generally more effective and may even provide long-term cures. Indian herbs like Boswellin are also a useful non toxic substitute and work better for those with rheumatoid arthritis.