Impaired insulin response appears to be involved in the development of Alzheimer‘s disease, according to a long-term population-based study.
Researchers analyzed data for more than 2,200 men who underwent glucose tolerance testing at the age of 50. After a follow-up at an average age of 32 years, 394 men developed dementia or mental impairments, including 102 with confirmed Alzheimer‘s disease and 57 with confirmed vascular dementia.
A low insulin response at the beginning of the study was associated with a 30 percent higher risk of Alzheimer‘s disease. Overall dementia and cognitive risks were associated with high fasting serum insulin, insulin resistance, impaired insulin secretion, and glucose intolerance.