June 07 2008
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People who receive blood-pressure-lowering drugs known as beta blockers shortly before, and after, having non-cardiac surgery are at higher risk of dying or having a stroke.
Surgery increases your heart‘s need for oxygen, and beta blockers are commonly given to help reduce blood pressure and heart rate, thereby reducing strain on the heart.
In the study of over 8,300 people, participants were randomly assigned to receive a beta blocker two to four hours before surgery, as well as for 30 days after the procedure, or a placebo.
Compared to those given a placebo, those who received beta blockers were 27 percent less likely to have a heart attack. However, they also had a 33 percent increased risk of dying, and double the risk of stroke.
An estimated 100 million people have major non-cardiac surgery each year, so the finding could have serious consequences. Even if only 10 percent of patients undergoing non-cardiac surgery were given beta blockers, that would mean that 800,000 people died unnecessarily in the past decade.