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June 28 2008
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Do Arthritis Drugs Cause Cancer?

arthritis drugsThe U.S. Food and Drug Administration (FDA) is investigating whether four drugs used to treat rheumatoid arthritis and other immune system diseases might increase the risk of cancer in children.

The FDA has received reports of 30 cases of cancer among children and young adults treated with the drugs. The agency did not make clear how many children had taken the drugs.

The drugs involved are:

1. Enbrel, sold by Amgen and Wyeth
2. Remicade, sold by Johnson & Johnson and Schering-Plough
3. Humira, sold by Abbott Laboratories
4. Cimzia, sold by the Belgian company UCB

All of the drugs block a protein called tumor necrosis factor, and are therefore known as TNF-blockers. They are used to treat not only rheumatoid arthritis but also psoriasis, Crohn’s disease and other immune diseases.

Because the drugs block part of the immune system, it’s long been known that they might contribute to a higher risk of cancers and infections. The drugs’ labels contain warnings as such, including warning about a risk of lymphomas, which are cancers of immune system cells.

Among adults, meanwhile, one study found that those given Humira or Remicade to treat rheumatoid arthritis had 2.4 times the cancer rate of those in control groups.

Dr. MercolaDr. Mercola's Comments:
Rheumatoid arthritis can be a devastating disease during which your body starts destroying itself, but there’s no need to wait for the FDA to investigate this one.

Most arthritis drugs are simply far too dangerous to use.

Studies had already linked Humira and Remicade, for instance, to:
  • Lymphoma
  • Tuberculosis
  • Pneumonia
  • Skin, gastrointestinal, breast and lung tumors
This was among adults, but the risks may be even more concerning among children, considering that the drugs suppress your immune system, and children’s immune systems are not yet mature.

It’s sad, though, because if you visit a rheumatologist most of them will prescribe these drugs right off the bat, as though they are the only option. And though they may help to ease your pain, they’re doing it at what expense? Cancer down the road? Tuberculosis? A lung tumor?

These are astronomical risks!

Not to mention that these drugs are expensive. The cost of using Remicade for one year is about $12,000. No, I did not put an extra zero in there. This explains why Remicade, Humira and Enbrel had combined sales of more than $13 billion in 2007.

If You Have Rheumatoid Arthritis, You do Have a Choice

Drugs are NOT the only option, and this is something that most doctors won’t tell you.

You have the choice to forgo arthritis drugs and their nasty side effects in favor of some lifestyle modifications. The following plan, which is based on my revision of Dr. Brown’s Antibiotic Protocol, has helped thousands of people with rheumatoid arthritis go into remission.

I have treated over 3,000 patients with this protocol since the late '80s and the success rate is well over 80%. It really is amazing how powerful the healing potential of your body is once you address causal factors and provide it with the essential healing tools and resources.

The protocol involves:

1. Improving your diet using a combination of my nutritional guidelines and nutritional typing.

2. Getting plenty of omega-3 fats by taking a high-quality, animal-based omega-3 supplement, like krill oil.

3. Getting your vitamin D levels checked and, if necessary, taking a supplement if you can't get daily sun exposure. This is absolutely crucial and, in my opinion, gross medical negligence and malpractice if it is not performed on nearly every RA patient as nearly all RA patients have low vitamin D levels

4. Having an effective method of addressing the nearly universal underlying emotional distresses that are present in most all autoimmune diseases like RA.

5. Incorporating regular exercise into your daily schedule. If your joints are painful, gentle exercises like yoga and Tai Chi are recommended. You may also want to have a consultation with an exercise professional so no permanent joint damage is done as a result of joint deformities.
 
What About Psoriasis and Crohn’s Disease?

Many people are also given arthritis drugs to treat these conditions, but these are two more examples of conditions that can be remedied without taking drugs that increase your risk of cancer.

About 7.5 million Americans have psoriasis, a skin disorder that causes scaly red patches. Carolyn Dean has written about some great natural methods to heal psoriasis, among them:
  • Increasing your intake of omega-3 fats
  • Dealing with stress in a healthy way
  • Eliminating sugar and refined and processed foods from your diet
I would add to that getting plenty of sun exposure to make sure your vitamin D levels stay where they need to be.

As for curing Crohn’s disease, a type of inflammatory bowel disease (IBD), naturally, the recommendations are much in the same:
  • Increase your intake of animal-based omega-3 fats, while decreasing your intake of omega-6 fats (found largely in vegetable oils)
  • Avoid sugar, as it will increase inflammation by increasing your insulin levels.
  • Avoid grains until symptoms are under control. Many with inflammatory bowel disease have gluten sensitivities. Additionally, the grains tend to increase insulin levels in most.
  • Make sure your vitamin D levels are optimized.
  • Get plenty of beneficial bacteria (probiotics) --which will help to heal your intestinal tract -- in your diet. Try cultured raw milk kefir for this purpose, or you can also consider a high-quality probiotic supplement.
Whatever you do, don’t let anyone suggest to you that drugs are the only way to handle immune diseases like rheumatoid arthritis, Crohn’s disease and psoriasis. You can get relief from your symptoms while healing the underlying causes by following the health principles I outlined above.

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Community Comments ( 21 )
Comment on this Article
  
  
All Under Heaven
[ Joined on 02/08 ] [ Posted on June 9, 2008 ]
3 Points        
   
 
Apprentice User
What else is new? All these drugs come with promises to treat this and that, but in the end it causes more sickness and death in a vicious cycle.

I agree, people are just brainwashed into believing the solution to anything comes in the form of a pill.

I used to respect Johnson and Johnson. Now I see they're no better than the rest of them. They denied Ortho Evra (birth control patch) was causing harm to women when it gave out several times fold the hormones. And now this...
 [ Reply ]
  
  
Aaltrude
[ Joined on 04/07 ] [ Posted on June 7, 2008 ]
2 Points        
   
 
Savvy User
This information reinforces the fact that it is far safer to find dietary means to control arthritis. As per my post to another topic today, studies have shown that one way this may be able to be achieved is by eliminating meat from your diet.
 [ Reply ]
Mercola
  
bmc
[ Joined on 02/07 ]  [ Posted on June 9, 2008]
4 Points        
   
Savvy User
  Mercola
I agree the first thing that should be done is to look at the persons diet, and have them make the necessary changes. People are so brain washed into asking for a pill, and too many doctors are brain washed that pills are the way to go. It's time to clean house in the medical world. That means clearing out big pharma and the insurance companies.
  
  
MarkEllins
[ Joined on 05/08 ] [ Posted on June 28, 2008 ]
1 Points        
   
 
Novice User

Great article!

I have found that the right adaptogens can have a huge impact on RA and IBS problems.

Good info is at:   www.miracleadaptogens.com

 [ Reply ]
  
  
rfontanes
[ Joined on 06/06 ] [ Posted on July 8, 2008 ]
       
   
 
Novice User

My 3 year elbow paines stopped after drinking Mangosteen fuit juice. Blueberry and Cherry may also help with inflamation.

 [ Reply ]
  
  
T_rex
[ Joined on 06/07 ] [ Posted on July 6, 2008 ]
       
   
 
Novice User

Take al these reports of harmful drug side effects and summarize it all into this blanketing statement:

ALL drugs are poisons.

 [ Reply ]
  
  
curious7
[ Joined on 03/07 ] [ Posted on July 1, 2008 ]
       
   
 
Apprentice User

Enbrel's label does indeed warn of a cancer danger.

 [ Reply ]
  
  
mmztcass
[ Joined on 06/06 ] [ Posted on June 30, 2008 ]
       
   
 
Novice User

I have had RA for over 15 years now.  I find that getting my mouth healthy with good teeth/gum cleaning and seeing biologic dentist is very helpful.  I hadn't had my teeth cleaned in 8 years and the inflammation was climbing higher and higher.  My dentist believes that a healthy or unhealthy mouth is the root to all diseases.  Now my inflammation rate is much lower.  I have also been on Methotrexate and Enbrel for over a year.  After two cleanings my inflammation was way down.  My last arthritis labs from three months ago showed huge improvements.

I went to have my teeth cleaned today and my hygienist says I no longer have any pockets and that I was back to normal.  Tomorrow I see the Rheumatologist for a three month visit and to get my labs.  I hope to see improvements to my labs.  If that is the case, the Rheumy will likely lower the RA meds that I will not have to take so much of.  I hope so.

I also recently began with supplements such as the greens and using vegetables and fruits to help me together with the multivitamins and the oils I take occasionally.  I have been a lifetime of a health nut.  So I work on balancing myself and if it has to be helped with using the meds as well as supplements, so be it.  I do agree that Lymphoma cancer rates are higher for those people who do not use any meds to ease the RA symptoms.  It's better if people on RA drugs can try to get by with less medicine than having to take more so it's not so toxic on their bodies.      

 [ Reply ]
  
  
Amicus Curiae1
[ Joined on 02/08 ] [ Posted on June 30, 2008 ]
       
   
 
Novice User

hi to all those who suffer from RA, i also have it. ten years ago they gave me 2 weeks to live, well i am here and sort of remitted i still live in fear of it coming back. from being so ill i could hardly breathe, sheets touching me causing agony, and unable to sleep for more than brief snatches, to wake in agony as you try and move a bit. and this hit me in a matter of weeks. age 38. i am 48 in a couple of weeks. so glad my refusal to believe the specialists got me through. yes i also took what i was asured was helpful, and i do love prednisalone.  well i did. sulphasalazime ,methotrexate pills, plaquenil, and naproxen 1000s almost knocked me off for good. amazing how a supposed specialist can not even allow a wash out time between such heavy duty meds. what "cured me" was good old gold jabs. 6  yrs worth. now i use melaleucas ProvexCV and it reduced the swollen hands that gold couldn,t it is grape and ginko and bioflavinoids and for me it helps, i find the vioxx and talam etc all cause way many bad effects and don,t dull pain better than a simple panadiene forte does.. Yes i know the codiene isnt great, but long term in moderation it is the lesser evil i think. no one here has mentioned the TENS machines? and i would now really go find a rife of holt type device if it flared badly again. i and others who share the same trait ie the RH factor does NOT show in our bloods , all seem to also have issues with the chondroitin...it either makes it worse or does no good we can feel, any others with this similarity out there?? as for support groups, i did find one among ebay groups a while back. the hospitals in aust at least, do not have much, and that is where you really need the help, especially as the docs do not really do much more than say , you have ra, heres a pill whatever, and you are on your own to come to grips with it. there is an Arthritis assoc in sth aust. but it seems to be for calls and to sell massively overpriced "aids" my sincere sympathy to all

 [ Reply ]
  
  
petite750
[ Joined on 11/07 ] [ Posted on June 29, 2008 ]
       
   
 
Novice User

I tried 3 or 4 chiropractors with different modalities.  3 had no effect, NUCCA did help and I still go to her for my neck.  It's very gentle and non-invasive, I haven't been on muscle relaxants for my neck in years because of the NUCCA.  

She also tried the little pen like ejector that does very small adjustments on the rest of the body, but my arthritis got worse each time, there is very little that doesn't set it off.  So I just have her do NUCCA on my neck, I'm happy with that.  Not sure if it affects my fibromyalgia positively, because I don't really notice the fibro; it's the mouse compared to the rheumtoid elephant.

I follow the various autoimmune and allergy diets pretty much, that helps alot.   The hardest thing when I was in so much pain for years was that I couldn't exercise at all.  The pool gave me bronchitis, and my joints were too swollen for anything else.  The doctor used to ask what time of day my stiffness & pain went away, and my response was that I've been waiting 8 years now for that to happen. Now I'm able to work out on the machines.  I also use the AYR sinus rinses twice daily, so I can go into the cool pool.  I love being able to exercise again!

The strongest drug I've taken was megadose of prednisone (steroid) for over a year for lungs, it was that or death.  Gave me cataracts, bone loss and teeth wearing away, and severe infections from the slightest cold.  Much stronger than Enbrel or Humira, or even infusions.  That's why I do juicing to build up immunity and calcium.

Non many support groups out there for arthritis, wish there was.

 [ Reply ]
  
  
petite750
[ Joined on 11/07 ] [ Posted on June 29, 2008 ]
       
   
 
Novice User

I've had rheumatoid arthritis for 10 yrs.  Very severe RA without the meds(!!) gives you 70 times the chance of getting lymphoma.  After trying all the alternative cures, I found only the strong drugs have significant positive effect. I was on Enbrel, am now on Orencia infusions and have taken large doses of prednisone for rheumatoid lung for a year.  I also altered my diet drastically, while it helps slightly, it doesn't begin to address the condition significantly.  Some supplements help, some make me worse.  Fish oil made me feel better, but caused large rheumtoid nodules as well, which is worse.  I even juice greens, ginger, etc daily, and take tart cherry juice for inflammation, the works.

I tried Dr. brown's antibiotic cure and found it has caused liver problems, something I never got even from Orencia infusions, Enbrel injections or large doses of prednisone.

The alternative stuff may work for some RA, but it doesn't touch very severe RA.  I say that as someone that never took even an aspirin before I got the RA.  The death rate for RA is pretty close to the same as it was in 1950.  30% die the first 10 years w/the illness.  Before these drugs came out, the average life expentancy for someone like me with very aggressive RA was 4 years.  

People don't take these meds because they don't know any better.  We take them because we want quality of life in the shortened time that we have, and nothing else we've tried has helped.  We know there is a trade off.  

 [ Reply ]
Mercola
  
cydwatts
[ Joined on 06/07 ]  [ Posted on June 29, 2008]
1 Points        
   
Novice User
  Mercola

When my roommate was 25, his hands were crippled with RA.  He'd had it for years at that point, but as a massage therapist, it became debilitating then.

Western medicine had kept him alive as a child (he had massive allergies and asthma, and spent much of his childhood in oxygen tents at hospitals because of double pneumonia).  He determined at that point to find an alternative.

What he found was a supplement made by the company Jarrow called Bone Up.  Two capsules twice a day greatly lessened his symptoms.  However, it did not cure the RA.

So he found, in looking for other alternatives, a Chinese Doctor.  This particular doctor practices traditional Chinese herbalism and acupuncture. Though he is a degreed MD, he does not practice that here because he feels we have enough MDs in the US.

In four years, this doctor CURED my friend's rheumatoid arthritis, his asthma, and his allergies.  A the age of 35, he ran across a parking lot.  It was the first time in his life he'd ever been able to run that far without falling down with an asthma attack.  At the same time, his knuckles are now the same size as his finger bones (roughly) rather than massively swollen as they had been all his life.  He's 46 now, and the problem remains gone.

Just because one or two alternatives don't work, there are many other, more effective, alternatives out there that are much safer than MD-style medicine.  Chinese medicine in particular has been a scientifically based practice for around 4,000 years, about 2,000 for acupuncture, where what we call "modern medicine" is really just that; it has been practiced as it is for less than 100 years.

I, personally, go with the longer successful track record.

Mercola
  
Vegas Liz
[ Joined on 09/06 ]  [ Posted on June 29, 2008]
-1 Points        
   
This user is BELOW novice level and all their comments need to be reviewed with great caution.
  Mercola

I have to agree with you. I tried alternative treatments for 10 years including antibiotic therapy. I could not achieve results to let me have a somewhat tolerable life. I was in constant pain. I have spent literally thousands of dollars on supplements trying to get the RA under control. The krill oil helped somewhat but nothing else enough to mention.I finally had to go on Enbrel 3 weeks ago. I did NOT want to but I had to. After 1 day, I started feeling relief and now I feel so much better. Getting sick is always in the back of my mind because I know this stuff reduces the immune system's function but I will just try to keep it as strong as possible with supplements.

If anyone has any suggestions on how to keep my immune system functioning while taking Enbrel, I would appreciate hearing them.

Be Well.

Mercola
  
petite750
[ Joined on 11/07 ]  [ Posted on June 29, 2008]
-1 Points        
   
Novice User
  Mercola

Thanks for the thoughts on what worked for your roommate.  I'm happy he found something.  Since he got it when he was young, it was important he found something less toxic.  My one friend is able to cut down on her Enbrel by taking Dr. Brown's antibiotic cure, and her knees are great, so that also works for some people.

I've found that each person reacts differently with RA. Mine is extremely aggressive, my doctor at a top hospital said I have the most aggressive she has ever seen.  I also have allergies, & joint reactions to medication & many supplements. I even swell as I said from fish oil & calcium.  The only joint damage I have is from the arthritis 'cure', glucosamine sulfate supplement.  

I didn't try a couple of alternatives, I spent five long years trying everything I could (spending tens of thousands of dollars), and still try new stuff occasionally.  I did the chinese accupuncture and Chinese herbal route for quite some time.  It helped slightly, but less than vioxx which was my least strength med.  All putzing around did was to cause contracture of my knee and I developed mild rheumatoid lung.  I nearly ended up in a wheelchair less than 2 years after getting it.

The dietary advice other RA sufferers gave me that did help was: avoid pop and ice cream, lower gluten (less grains) and work out in the pool.

I've lost 10 long years to fighting this disease.  I'm now 58, so I want to enjoy my life.  If it takes these toxic meds, and it seems to, that's the trade off.

Mercola
  
etbsndc
[ Joined on 08/06 ]  [ Posted on June 29, 2008]
       
   
Apprentice User
  Mercola

Just out of curiosity, I am wondering if the folks with the horrendous RA problems have added Chiropractic to their list of possibilities in dealing with it.  Who know how many people could benefit from this non-toxic/invasive way to help the body function the very best that it can.  Strange things can happen to our bodies when the proper information does not reach its target organs or events.  My best wishes to all of you in your search for better health.

  
  
Thinker
[ Joined on 06/06 ] [ Posted on June 28, 2008 ]
       
   
 
Novice User

My experience over the past 20 years is that almost every person with an autoimmune disease like rheumatoid arthritis suffers from heavy metal and chemical toxicity, usually both, which cause mitochondrial dysfunction  and free radical production leading to severe inflammation.  Autoimmune disorders are produced experimentally by injecting mercury into anumals.  Hair analysis is very effective at revealing the presence of heavy metals and is readily available.  Subsequent chelation plus natural herbal anti-inflammatory agents are almost invariably helpful.  Replacement of amalgam fillings is often necessary to achieve the best results.  Check out www.scienceformulas.com.

 [ Reply ]
  
  
KelleyEidem
[ Joined on 11/07 ] [ Posted on June 28, 2008 ]
       
   
 
Novice User

RA is an auto immune disease. As such, it is most often caused by leaky gut. My protocol for ending food cravings and flattening your tummy effortlessly applies equally to RA, with the addition of fish oil to help balance the metabolism.

Here's the link: www.squidoo.com/foodcravings

The best to you.

Kelley Eidem

 [ Reply ]
  
  
Jinny
[ Joined on 06/06 ] [ Posted on June 28, 2008 ]