Polyphenols Halt Prostate Cancer Growth
June 29, 2010
Scientists believe they now know exactly why polyphenols, such as those found in red wine and green tea, inhibit cancer growth. The antioxidants produce a combined effect to disrupt an important cell signaling pathway necessary for prostate cancer growth.
The SphK1/S1P signaling pathway plays a role both in prostate cancer and in other cancers such as colon cancer, breast cancer, and gastric cancers.
"Scientists conducted in vitro experiments which showed that the inhibition of the sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway was essential for green tea and wine polyphenols to kill prostate cancer cells ... Human prostate cancer cells were implanted in the mice and results showed a dramatic decrease in tumor size in the mice drinking the EGCG or polyphenon E mixtures."