Microbiologist Philip Tierno, when he has to stay in hotels, travels with an impervious mattress and pillow cover. Lurking in every hotel mattress are skin cells, human hair, bodily secretions, fungi, bacteria, dust, dust mites, lint, insect parts, pollen, and cosmetics.
Tierno encourages everyone to use the impervious covers developed for allergy sufferers. And he also advises that you definitely get rid of the bedspread. The first thing he does is remove the comforter and store it in the closet. CNN reports:
"It's certainly true that bedspreads, or the quilts inside duvet covers, don't get thrown in with the sheets for a daily wash ... Germs ... tend to congregate in places touched multiple times by multiple people that may not be cleaned thoroughly, if at all".