New Discovery Shakes the Foundation of Cancer Research
October 15, 2011
- Two widely cited, published cancer research studies contain fabricated data, will be retracted
- The Mayo Clinic concluded that data about harnessing the immune system to fight cancer had been fabricated, resulting in the retraction of 17 papers in nine research journals
- Cancer research in the United States needs to be scrutinized, as much is money-driven and based on developing new drugs
By Dr. Mercola
In a scandal that has reverberated around the world of cancer research, the Office of Research Integrity at the U.S. Department of Health found that a Boston University cancer scientist fabricated his findings.
His work was published in two journals in 2009, and he’s been ordered to retract them. But important studies by other scientists like those at the Mayo Clinic, who based their work on his findings, could now make 10 years of their studies worthless, according to commentary in Gaia Health.
It seems fairly evident that the cancer industrial complex is a highly lucrative, well-oiled system that tends to support funding for expensive drug treatments that don't address the cause of the problem, and have yet to make a significant dent in the decrease of the overall cancer rate in the US despite investing hundreds of billions of dollars.
Much of the support comes from flawed and biased "research" studies that support the use of expensive drugs as detailed in the featured articles.
Researchers, too, are well aware of the notoriety and money to be found in cancer research … particularly what may be deemed successful cancer research (which unfortunately is often measured by the discovery of new drug treatments).
But, as with many areas of medical research, it's important to read between the lines of "scientifically proven" studies, even those that are well accepted.
Often what you'll find is the research gives the perception of science when really it is a heavily manipulated process designed to control and deceive. Case in point, here again we have an example of widely accepted, published research that turned out to be fabricated.
10 Years of Cancer Research Down the Drain
The Office of Research Integrity (ORI) at the U.S. Department of Health reported in August 2011 that final action has been taken against Sheng Wang, PhD, of Boston University School of Medicine, Cancer Research Center. ORI states:
"The Respondent engaged in research misconduct by fabricating data that were included in two (2) published papers."
- Oncogene February 2009, which found that HIC1, a protein thought to suppress tumor growth, is a "central molecule in a novel mechanism controlling cell growth and that the disruption of this HIC1-mediated pathway may lead to abnormal cell proliferation and, ultimately, cancer."
- Molecular Endocrinology December 2009, which found "reintroducing HIC1 into resistant breast cancer cells restored their sensitivity to the estrogen antagonists, indicating the existence of a novel regulatory mechanism for growth control of breast cancer cells."
Specifically, six of the eight figures in the Oncogene paper and six of the seven figures in the Molecular Endocrinology study were said to contain data from fabricated experiments. Though Wang is now required to retract the papers, and he reportedly stopped working for Boston University in July, he will only be ineligible for federal funding for 2 years.
Further, the fabricated research may continue to live on, as it has been cited by other studies and once a finding is accepted in the medical community, it's very hard to make it go away. Unfortunately, scientific retractions are actually becoming increasingly common.
As the Wall Street Journal reported:
"Just 22 retraction notices appeared in 2001, but 139 in 2006 and 339 last year. Through seven months of this year, there have been 210, according to Thomson Reuters Web of Science, an index of 11,600 peer-reviewed journals world-wide …
At the Mayo Clinic, a decade of cancer research, partly taxpayer-funded, went down the drain when the prestigious Minnesota institution concluded that intriguing data about harnessing the immune system to fight cancer had been fabricated. Seventeen scholarly papers published in nine research journals had to be retracted. A researcher, who protests his innocence, was fired. In another major flameout, 18 research journals have said they are planning to retract a total of 89 published studies by a German anesthesiologist …"
Fabricated Research is More Common Than You Might Think
Peer-reviewed research published in medical journals gets the golden star of approval in the media, yet many, if not most, of the findings are incredibly misleading. One of the best exposé's into this muddled system came from none other than Dr. Marcia Angell, who was the former editor-in-chief of the New England Journal of Medicine (NEJM).
In her book The Truth about Drug Companies: How They Deceive Us and What to Do About It, she exposed many examples of why medical studies often cannot be trusted, and said flat out:
"Trials can be rigged in a dozen ways, and it happens all the time."
For instance, in 2009 Dr. Scott Reuben, who was a well-respected, prominent anesthesiologist, former chief of acute pain of the Baystate Medical Center, Springfield, Mass. and a former professor at Tufts University's medical school, allegedly fabricated the data for 21 studies!
Dr. Reuben succeeded in getting numerous studies published, and those studies were accepted as fact and swayed the prescribing habits of doctors. It was only due to a routine audit raising a few red flags that a larger investigation was later launched.
So how did those false studies, or any studies for that matter, become worthy of being published? Part of the problem may be the peer-review process itself, as this puts researchers in charge of policing other researchers' results, and most do not want to insult a fellow researcher's work with negative comments.
As written in Gaia Health:
"It's all about money. Get published in a major medical journal and your future is made. Most peer reviewers are doing their own studies. That's what makes them peers. They want to be able to publish. Therefore, they are not particularly inclined to make more than perfunctory negative comments. Obviously, they don't want to alienate the authors of papers, since they either are or hope to become published themselves.
Peer review is a farce. The only kind of review that makes real sense is professional independent reviewers. Yet, for decades we've had peer review trotted out as the be-all and end-all in determining the legitimacy of papers. It's been unquestioned, while a little examination of the concept demonstrates that it's nearly certain to result in fraudulent work being passed as good science."
It's almost impossible to find out what happens in the vetting process, as peer reviewers are unpaid, anonymous and unaccountable. And although the system is based on the best of intentions, it lacks consistent standards and the expertise of the reviewers can vary widely from journal to journal.
Given that cancer research is such a lucrative business right now -- the National Cancer Institute, which gave the grant money to support Dr. Sheng Wang's fabricated research, had a $5.1 billion budget for fiscal year 2010 -- the stakes are exceptionally high. So it stands to reason that it may be subject to even more fraud and manipulation than less lucrative research prospects.
As The Economist reported, there were more new cancer drugs in development in 2010 than any other therapeutic area. Drug makers are well aware that a blockbuster cancer drug could easily earn them profits in the billions, even if the drug is only borderline effective. It is abundantly clear that profit is a primary motive of these companies so it should not be a surprise that they have moved in this direction, and this is where the abundance of research is focused as well.
Why You Might Want to Think Twice Before Donating to Anti-Cancer Charities
A lot of people put their faith in charity organizations like the American Cancer Society (ACS), dutifully donating money to help in the "war on cancer." But in the report titled American Cancer Society—More Interested In Accumulating Wealth Than Saving Lives, Dr. Samuel S. Epstein, chairman of the Cancer Prevention Coalition, plainly lays to bare the many conflicts of interest that hamper the effectiveness of this organization.
For example, the ACS has close financial ties to both makers of mammography equipment and cancer drugs. But that's just for starters. Other conflicts of interest include ties to, and financial support from, the pesticide-, petrochemical-, biotech-, cosmetics-, and junk food industries—the very industries whose products are the primary contributors to cancer!
The ACS, along with the National Cancer Institute, virtually exclusively focus on cancer research and the diagnosis and chemical treatment of cancer. Preventive strategies, such as avoiding chemical exposures, receive virtually no consideration at all.
"Giant corporations, which profited handsomely while they polluted air, water, the workplace, and food with a wide range of carcinogens, remain greatly comforted by the silence of the ACS. This silence reflected a complex of mindsets fixated on diagnosis, treatment, and basic genetic research, together with ignorance, indifference, and even hostility to prevention. Not surprisingly, the incidence of cancer over past decades has escalated, approximately parallel to its increased funding," Dr. Epstein writes.
Many also do not realize that when you donate money to the American Cancer Society, the majority of it may never go further than the bank accounts of its numerous well-paid executives.
Meanwhile, global cancer rates have doubled in the last three decades, and their "war on cancer" strategy completely ignores, and oftentimes denies, the obvious links between cancer and toxic exposures through pesticide-laden foods, toxic personal care products, cancer-causing medical treatments and drugs, and industrial pollution. We CAN turn this trend around, but to do so the medical and research communities must stop focusing on drug treatments and overlooking the methods that can actually have a significant impact on preventing this disease.
My Top 12 Tips for Cancer Prevention
Rather than put your health in the hands of cancer researchers willing to do just about anything to discover the next cancer drug breakthrough, take control of your health by following the cancer-preventive lifestyle changes below.
- Avoid Fructose and Sugar
It's quite clear that if you want to avoid cancer, or are currently undergoing cancer treatment, you absolutely MUST avoid all forms of sugar -- especially fructose -- and this is largely due to its relation to insulin resistance. According to Lewis Cantley, director of the Cancer Center at Beth Israel Deaconess Medical Center at Harvard Medical School, as much as 80 percent of all cancers are "driven by either mutations or environmental factors that work to enhance or mimic the effect of insulin on the incipient tumor cells," Gary Taubes reports.
Some cancer centers, such as the Cancer Centers of America, have fully embraced this knowledge and place their patients on strict low-sugar, low-grain diets. But conventional medicine in general has been woefully lax when it comes to highlighting the health dangers of this additive.
As a standard recommendation, I strongly advise keeping your TOTAL fructose consumption below 25 grams per day including fruits. But for most people it would also be wise to limit your fructose from fruit to 15 grams or less, as you're virtually guaranteed to consume "hidden" sources of fructose if you drink beverages other than water and eat processed food.
- Optimize Your Vitamin D Level
There's overwhelming evidence pointing to the fact that vitamin D deficiency plays a crucial role in cancer development. Researchers within this field have estimated that about 30 percent of cancer deaths -- which amounts to 2 million worldwide and 200,000 in the United States -- could be prevented each year simply by optimizing the vitamin D levels in the general population.
On a personal level, you can decrease your risk of cancer by MORE THAN HALF simply by optimizing your vitamin D levels with sun exposure. And if you are being treated for cancer it is likely that higher blood levels—probably around 80-90 ng/ml—would be beneficial.
If the notion that sun exposure actually prevents cancer is still new to you, I highly recommend you watch my one-hour vitamin D lecture to clear up any confusion. It's important to understand that the risk of skin cancer from the sun comes only from excessive exposure.
If you are like most people, when you think of reducing your risk of cancer, exercise doesn't immediately come to mind. However, there is some fairly compelling evidence that exercise can slash your risk of cancer. One of the primary ways exercise lowers your risk for cancer is by reducing elevated insulin levels, which creates a low sugar environment that discourages the growth and spread of cancer cells.
For example, physically active adults experience about half the incidence of colon cancer as their sedentary counterparts, and women who exercise regularly may reduce their breast cancer risk by 20 to 30 percent compared to those who are inactive.It's important to include a large variety of techniques in your exercise routine, such as strength training, aerobics, core-building activities, and stretching. Most important of all, however, is to make sure you include high-intensity, burst-type exercise, such as those described in my Peak Fitness program.
These exercises activate your super-fast twitch muscle fibers, which can increase your body's natural production of human growth hormone. For detailed instructions, please see this previous article.
- Get appropriate amounts of high quality animal-based omega-3 fats.
- Eat according to your nutritional type. The potent anti-cancer effects of this principle are very much underappreciated. When we treat cancer patients in our clinic this is one of the most powerful anti-cancer strategies we have.
- Engage in activities that help you reduce your stress levels, such as exercise, meditation, journaling, music, gardening, etc. Even the CDC states that 85 percent of disease is caused by emotions. It is likely that this factor may be more important than all the other physical ones listed here, so make sure this is addressed.
- Only 25 percent of people eat enough vegetables, so by all means eat as many vegetables as you are comfortable with. Ideally, they should be fresh and organic. Cruciferous vegetables in particular have been identified as having potent anti-cancer properties. Remember that carb nutritional types may need up to 300 percent more vegetables than protein nutritional types.
- Maintain an ideal body weight.
- Get appropriate amounts of high-quality sleep.
- Reduce your exposure to environmental toxins like pesticides, household chemical cleaners, synthetic air fresheners and air pollution.
- Reduce your use of cell phones and other wireless technologies, and implement as many safety strategies as possible if/when you cannot avoid their use.
- Boil, poach or steam your foods, rather than frying or charbroiling them. Better yet eat as many of your foods raw as you can.