Major Depression and Cigarette Smoking May Share Common Cause

It appears not only that a history of major depression increases the risk of progression to daily smoking, but also that a history of smoking on a daily basis is a risk factor for development of major depression. And those findings, a multicenter team says, provide reasons to suspect that daily smoking and major depression share a number of etiological factors. They researchers cite the possibilities that smoking might be a self-medication for depressed mood and that neuropharmacologic effects of nicotine could be associated with depression.

Arch Gen Psych 1998;55:161-166

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