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The US Food and Drug Administration (FDA) and the pharmaceutical company Pfizer advised doctors last week about new warnings and information added to the labeling of the impotence drug sildenafil (Viagra). The changes have been made in response to reports of cardiovascular adverse events in patients using the drug and nitrate heart drugs. According to the FDA's last surveillance update, there were 123 deaths worldwide reported from March through July 1998 for patients taking sildenafil. Of the 69 men who died in the US, 74% had one or more risk factor for cardiovascular or cerebrovascular disease, the agency said.
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