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In the fall of 1999, SmithKline Beecham secretly began a study to find out if its diabetes medicine, Avandia, was safer for the heart than a competing pill. The study's results were disastrous. Not only was Avandia no better than Actos, but the study also provided clear signs that it was riskier to the heart.
Instead of publishing the results, the company spent the next 11 years trying to cover them up. The company did not submit the results to federal drug regulators, as is required by law.