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FDA Finally Changes Prescription Recommendations for High-Dose Acetaminophen

Acetaminophen

Story at-a-glance -

  • Acetaminophen overdose is the leading cause for calls to Poison Control Centers across the US—more than 100,000 instances per year
  • Each year, acetaminophen overdose is responsible for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure
  • Acetaminophen poisoning is responsible for nearly HALF of ALL acute liver failure cases in the US. It can be toxic to your liver even at recommended doses when taken daily for just a couple of weeks
  • While rare, it’s also worth noting that acetaminophen has been linked to very serious skin reactions
  • The FDA has issued a statement urging health professionals to discontinue prescribing and dispensing prescription combination drug products containing more than 325 mg of acetaminophen per dose
One of the country's most popular over-the-counter painkillers — acetaminophen, the active ingredient in Tylenol — also kills the most people, according to data from the federal government. Over 150 Americans die each year on average after accidentally taking too much. And it requires a lot less to endanger you than you may know. We reported this alongside ProPublica.