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Glycine Quells Oxidative Damage by Inhibiting NOX Superoxide Production and Boosting NADPH

Analysis by Dr. Joseph Mercola Medically Reviewed by Dr. James DiNicolantonio Fact Checked

glycine supplementation

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  • Glycine is mildly sweet and can be used as a sugar substitute in tea or coffee
  • Glycine and collagen (an outstanding source of glycine) inhibits the consumption of NADPH, thereby lowering inflammation and oxidative damage
  • NADPH oxidase is typically abbreviated as NOX. Inhibiting NOX is an effective way to increase NADPH and your cells’ ability to reduce oxidative stress
  • NADPH is used as a reductive reservoir of electrons to recharge antioxidants once they become oxidized. NADPH is also necessary to make your steroid hormones and fats
  • Preventing many chronic diseases requires finding a means of inhibiting or modulating NOX. Such strategies include avoiding fructose, practicing nutritional ketosis and supplementing with spirulina, niacin, glycine and collagen
  • Glycine supplementation may be beneficial for the prevention and/or treatment of metabolic syndrome, complications from diabetes, cardiac hypertrophy, and alcoholic and nonalcoholic liver disorders

As you probably know, inflammation and oxidative damage are primary drivers of most chronic diseases. What you may not be aware of is the importance of nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) and NADPH oxidase, typically abbreviated as NOX, in these processes.

In a recent paper, James DiNicolantonio, who also co-wrote my latest book “Superfuel,” details the importance of collagen and glycine for the inhibition of NADPH breakdown.  DiNicolantonio, who also has a new book with Jason Fung, called “The Longevity Solution,” takes a deep dive into how collagen and glycine may help promote longevity.


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