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The Longevity Solution — Rediscovering Centuries-Old Secrets to a Healthy, Long Life

Analysis by Dr. Joseph Mercola Fact Checked

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  • While excess protein can activate mTOR, your protein needs do increase with age, as you need to counteract progressive loss of muscle mass. So, your age really needs to be taken into account
  • Protein requirements range from 0.6 grams per kilo of lean body mass in adulthood, up to 2 grams per kilo of lean body mass for young children. The elderly, bodybuilders and endurance athletes typically have higher than normal protein requirements for their age group
  • It’s important to cycle high and low protein intake. Ideally, combine protein restriction with fasting, followed by increased protein intake on strength training days
  • Other nutrients that activate mTOR include branched-chain amino acids, glutamine, methyl folate and vitamin B12; nutrients that inhibit mTOR include curcumin, fisetin and polyphenols such as quercetin, resveratrol and epigallocatechin gallate
  • Fasting 16 to 18 hours each day is ideal, as this allows your body to deplete the glycogen stores in your liver to a greater degree and suppress mTOR and activate autophagy better

Dr.Jason Fung, a nephrologist and author of two previous books, "The Obesity Code" and "The Complete Guide to Fasting," has now released a third, "The Longevity Solution," which is the topic of this interview. This book was also co-written with James DiNicolantonio, Pharm. D, who also happens to be the co-author of my latest book, "Superfuel."

The motivation for "The Longevity Solution" came from a discussion with DiNicolantonio. "He'd already talked about salt in his book, 'The Salt Fix.' In 'Superfuel,' he talked about good fats, bad fats and super fuel. We thought it would be great to tie everything together in terms of the real dietary determinants of longevity," Fung says, adding:

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