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Sunscreen Safety Questioned Yet Again

Analysis by Dr. Joseph Mercola Fact Checked

oxybenzone sunscreen

Story at-a-glance -

  • A 2019 study by the U.S. FDA shows four common active ingredients in sunscreen — avobenzone, oxybenzone, octocrylene and ecamsule — are absorbed into your blood at levels that could potentially pose health risks
  • Systemic concentrations greater than 0.5 ng/mL were reached for all four products after four applications on the first day; 0.5 ng/mL is the FDA maximum threshold for waiving systemic carcinogenicity, developmental and reproductive toxicology studies for sunscreens
  • Follow-up research confirms systemic concentrations of sunscreen chemicals are up to 500 times higher than the FDA’s assumed safety threshold
  • Oxybenzone and several other active ingredients in sunscreens enhance the ability of other chemicals to penetrate your skin, including toxic herbicides, pesticides and insect repellants, and act as endocrine disrupters
  • Despite the endocrine disrupting and neurotoxic effects of oxybenzone, its high absorbability, and the availability of safe sunscreens (those containing non-nanosized zinc oxide and titanium dioxide), the FDA and American Academy of Dermatology urge people to continue using oxybenzone-containing sunscreen on a daily basis

Conventional guidance to avoid unprotected sun exposure at all costs has likely done public health a great disservice. The American Academy of Dermatology,1 for example, stresses daily use of sunscreen to prevent skin cancer, regardless of weather conditions or skin pigmentation — two factors that simply cannot be overlooked when weighing the risks and benefits of sun exposure and sunscreen use.2

A direct result of this blanket recommendation is widespread vitamin D deficiency, which we now know is a risk factor for a wide variety of cancers and many other chronic diseases. Your vitamin D level even influences your risk of skin cancer.

For example, a 2010 study3 found elderly men with the highest quintile of vitamin D had a 47% lower risk of non-melanoma skin cancer compared to those with the lowest levels. Research4 has also shown vitamin D deficiency worsens your prognosis if you have metastatic melanoma.

What’s more, research5,6 shows your risk of developing melanoma from sun exposure is exceedingly small to begin with — well below 1% — and your risk of developing melanoma does not disappear by avoiding sun exposure. It's just one-tenth of 1% lower than if you got frequent exposure.

The science is not cut and dry, however. You can certainly find studies to make an argument for both sides of the issue, i.e., that sun exposure can increase your risk of skin cancer, or lower it. A key argument that tends to get lost in the discussion, though, is the importance of vitamin D for overall health and disease prevention.

In my view, it seems foolish to prevent one disease using a strategy that will increase your risk of many others, including — most importantly — shortening your overall life span.7,8 Aside from promoting vitamin D deficiency, daily sunscreen use is also a source of significant toxic exposure.

Your Body Absorbs Toxins From Sunscreens

In 2019, the U.S. Food and Drug Administration published a pilot study9,10,11,12 showing four commonly used active ingredients in sunscreen — avobenzone, oxybenzone, octocrylene and ecamsule — are absorbed into your blood at levels that could potentially pose health risks.

Twenty-four participants were asked to apply 2 milligrams (mg) of sunscreen per square centimeter over 75% of their body, using either one of two sprays, a lotion or a cream. This amount equates to the maximum recommended dose recommended by most makers of sunscreen.

A total of 30 blood samples were collected from each participant over seven days of application. The geometric mean maximum plasma concentrations were as follows for each of the chemicals:13

  • Oxybenzone — 209.6 nanograms per milliliter (ng/mL) for spray No. 1; 194.9 ng/mL for spray No. 2, and 169.3 ng/mL for lotion
  • Avobenzone — 4 ng/mL for spray No.1; 3.4 ng/mL for spray No. 2; 4.3 ng/mL for lotion and 1.8 ng/mL for the cream
  • Octocrylene, — 2.9 ng/mL for spray No. 1; 7.8 ng/mL for spray No. 2; 5.7 ng/mL for lotion, and 5.7 ng/mL for cream
  • Ecamsule — 1.5 ng/mL for cream

As noted by the authors,14 systemic concentrations for all four products were greater than 0.5 ng/mL after four applications on the first day. Below this threshold of 0.5 ng/mL, the FDA will typically waive nonclinical toxicology studies for sunscreens. Since all four chemicals exceeded the safety threshold, the agency determined that additional toxicology assessment would be required.

Now, it bears mentioning that the safety threshold of 0.5 ng/mL is based on the FDA’s regulation of food packaging substances,15 not chemicals that are absorbed through your skin.

Chemicals that migrate from packaging into food are ingested, whereas sunscreen chemicals are absorbed through your skin directly into your bloodstream, bypassing your digestive tract, which has the ability to filter out some of the toxins. In short, there’s no telling whether the 0.5 ng/mL threshold is actually safe and appropriate for these (and other) sunscreen chemicals.

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Follow-Up Research Confirms Previous Finding

January 21, 2020, the FDA research team published a follow-up study16,17 on 48 adults using an expanded lineup of active sunscreen ingredients. This time, they looked at avobenzone, oxybenzone, octocrylene, homosalate, octisalate and octinoxate in lotion; aerosol spray; nonaerosol spray; and pump spray form.

Participants applied 2 mg of sunscreen per square centimeter over 75% of their body at two-hour intervals at baseline and on days 2, 3 and 4. Blood samples were collected over 21 days. Geometric mean maximum plasma concentrations for the various ingredients and products were as follows (listed from highest to lowest concentrations):

Oxybenzone

Lotion — 258.1 ng/mL

Aerosol spray — 180.1 ng/mL

Homosalate

Aerosol spray — 23.1 ng/mL

Nonaerosol spray — 17.9 ng/mL

Pump spray — 13.9 ng/mL

Octinoxate

Nonaerosol spray — 7.9 ng/mL

Pump spray — 5.2 ng/mL

Octocrylene

Lotion — 7.8 ng/mL

Aerosol spray — 6.6 ng/mL

Nonaerosol spray — 6.6 ng/mL

Avobenzone

Lotion — 7.1 ng/mL

Aerosol spray — 3.5 ng/mL

Nonaerosol spray — 3.5 ng/mL

Pump spray — 3.3 ng/mL

Octisalate

Aerosol spray — 5.1 ng/mL

Nonaerosol spray — 5.8 ng/mL

Pump spray — 4.6 ng/mL

As in the first study, oxybenzone concentrations were about 400 to 500 times higher than the presumed safety threshold after just a couple of days’ use. Despite that, the FDA continues to urge Americans to use sunscreen.

The justification for this recommendation, as noted by Drs. Adewole S. Adamson and Kanade Shinkai in an accompanying editorial,18 is the “absence of clear data demonstrating harm.” Alas, oxybenzone in particular has been linked to a variety of potential health problems, including allergies, hormone disruption and cell damage.19

Oxybenzone Is Far From Harmless

Importantly, research shows oxybenzone and several other active ingredients in sunscreens enhance the ability of other chemicals to penetrate your skin, including toxic herbicides, pesticides and insect repellants.

According to a study20 published in 2004, oxybenzone, octyl methoxycinnamate, homosalate, octyl salicylate, padimate-o and sulisobenzone all significantly increased absorption of the herbicide 2,4-D, which can be a significant concern for agricultural workers in particular.

Oxybenzone (as well as at least eight other sunscreen ingredients21,22) also acts as an endocrine disrupter, and research23 published in 2018 warned it can induce changes in the breasts when used during pregnancy and lactation. According to the authors:

“These data suggest that oxybenzone, at doses relevant to human exposures, produces long-lasting alterations to mammary gland morphology and function. Further studies are needed to determine if exposure to this chemical during pregnancy and lactation will interfere with the known protection that pregnancy provides against breast cancer.”

Other studies have shown oxybenzone:

Is a phototoxicant, which means its adverse effects, and its ability to form harmful free radicals, are magnified when exposed to light,24 which of course is the primary use of the product

Is neurotoxic (toxic to your brain)25

Can “significantly lower” testosterone levels in adolescent boys26

Reduces sperm count in men27

Alters hormone levels in men, specifically testosterone, estradiol and inhibin B28

Is linked to endometriosis in women29

Increases male infertility by affecting calcium signaling in sperm, in part by exerting a progesterone-like effect30

Can result in lower male birth weight and decreased gestational age31

Is lethal to certain sea creatures, including horseshoe crab eggs, and poses a serious threat to coral reefs and sea life32,33,34

Considering the endocrine disrupting and neurotoxic effects of oxybenzone, its high absorbability, and the availability of safe sunscreens (those containing non-nanosized zinc oxide and titanium dioxide), it seems rather irrational to continue using oxybenzone-containing sunscreen to protect yourself against skin cancer.

Research35 by the U.S. Centers for Disease Control and Prevention published in 2008 found 96.8% of the 2,517 urine samples collected as part of the 2003-2004 National Health and Nutrition Examination Survey had detectable levels of oxybenzone, which is a testament to just how much sunscreen people are using. And this data is 15 years old. It is likely far worse now.

Safer Sunscreens Are Available

When selecting a sunscreen, it’s important to realize there are only two known safe sunscreen ingredients — zinc oxide and titanium dioxide36 — and they must not be nanosized, as nanoscale zinc oxide37 and titanium dioxide38 have their own health risks.

Your safest choice is a lotion or cream with non-nanoscale zinc oxide, as it is stable in sunlight and provides the best protection from UVA rays.39 Your next best option is non-nanoscale titanium dioxide.

Also keep in mind that the sun protection factor (SPF) only tells you the level of protection you get from UVB rays (the rays within the ultraviolet spectrum that allow your skin to produce vitamin D), not UVA (which penetrate deeper and are responsible for much of the skin damage associated with excessive sun exposure.

So, make sure the product you select is labeled “broad spectrum SPF,” which indicates the product protects against both UVA and UVB. As a general rule, avoid sunscreens with an SPF above 50. While not intrinsically harmful, the higher SPF tends to provide a false sense of security, encouraging you to stay in the sun longer than you should.

Moreover, higher SPF typically does not provide much greater protection. In fact, research suggests people using high-SPF sunscreens get the same or similar exposure to UV rays as those using lower-SPF products.

What’s more, an analysis40 by Consumer Reports found many sunscreens are far less effective than claimed on the label; 32 of the 82 products evaluated for 2019 offered less than half the protection promised by their stated SPF. Consumer Reports said they’d seen “a similar pattern in previous years’ sunscreen tests.”

The Environmental Working Group’s Skin Deep Database is a good resource when evaluating your sunscreen choices. Dr. Mercola Sunscreen SPF 30 received the EWG’s highest safety rating in 2017.41

+ Sources and References