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For the millions of Americans, warnings
about the carcinogenic effects of excessive sun exposure have
come too little or too late.
But a panel of dermatology experts report
that a number of common topical and edible agents are now
being tested for their ability to slow or prevent the onset
of disease among those already overexposed to ultraviolet
(UV) radiation.
Tanning "is a protective maneuver
by your body in response to skin damage, so there is no
'safe' tan," stressed panel speaker Dr. James M.
Spencer. "But for those who didn't know any better...there
are many steps between overexposure to the sun and developing
skin cancer, and so there are many places we could intervene
to stop the process."
As director of the division of Dermatologic
Surgery at the Mount Sinai School of Medicine in New York
City, Spencer reviewed the latest advances in "chemoprevention"
-- the clinical term for the inhibition and reversal of the
aging process and cancer brought on by UV radiation. Experts
estimate that more than 1 million new cases of skin
cancer will be diagnosed in the US this year.
Spencer highlighted one recent study that
found a 5-year regimen of oral vitamin A significantly
reduced the formation of certain types of skin cancer cells
among almost 2,300 patients who had a history of precancerous
skin abnormalities and were at moderate risk of full-blown
skin cancer.
The researcher pointed out, however, that
potentially serious side effects such as liver inflammation
and elevated cholesterol levels make vitamin A a less-than-ideal
treatment, and that those at very high risk of skin cancer
did not seem to benefit.
But Spencer added that other research
is focusing on the link between diet and cancer prevention,
with green tea and soybeans standing out as two of the most
promising foods. He noted that certain antioxidants in green
tea -- the second most widely consumed beverage in the world
after water -- and certain isoflavones found in soy products
seemed to stop the growth of tumors in early animal studies.
Other preliminary findings suggest that
a diet low in fat, or higher in unsaturated fat
than saturated fat, may also result in fewer skin tumors,
he said. Even aspirin and over-the counter nonsteroidal anti-inflammatory
medicines appear to have chemopreventative effects, Spencer
added.
Since it can take 10 to 20 years for the
effects of sun damage to appear on the skin, these new treatments
may in the long run prove to be lifesavers following sun exposure,
Spencer told Reuters Health. But he cautioned that research
is ongoing and inconclusive to date, so consumers should
not to hastily embark on any vitamin or food program --
particularly those with side effects.
"As long as it's a trivial intervention
such as incorporating soy in your diet, then it may very well
be helpful, but vitamin A would not be since it has serious
side effects," he said. "Green tea belongs in the
lab at this point," he added. "It's a maybe. It's
certainly not proven. This is an exciting horizon for the
future -- but we're not there yet."
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