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Giving migraine patients the drug valproate
sodium "rapidly and forcefully" eases severe headaches
without side effects.
Patients were given injections of 100
milligrams (mg) of the anti-seizure drug Depakote (valproate
sodium) every 5 minutes
until their pain was relieved. On average, patients
received 720 mg of the drug and achieved maximum
pain relief in 50 minutes.
Patients' average rating for symptom
relief was 88%, and many reported complete
pain relief. No problems with drowsiness or euphoria
were reported, although most patients said they felt very
calm after treatment.
Headache Quarterly
2001;12:39-41
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