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January 19 2005
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Vitamin A: Little Known Secret to Preventing Breast Cancer

 

It has long been suspected that vitamin A may be linked to cancer prevention. The mechanisms by which this may be happening, however, have yet to be understood. Conversely, scientists have discovered that a malfunction in the way the body processes vitamin A may be the culprit behind the formation of breast cancer.

Vitamin A, or retinol, can be found in a number of food products, such as cod liver oil, milk, eggs and fruits and vegetables; however, too much vitamin A can be toxic to the body.

Vitamin A Processing

  • Once the vitamin enters the body, it is stored in the liver and other tissues, including the breast

  • When it is needed, the vitamin is converted into retinoic acid, activating the retinoic acid receptor in the cells

  • The receptor regulates the expression of a variety of genes, most of which are associated with cell differentiation

  • When cell differentiation occurs, the genes turn into cells with specific roles to play; cells that don't differentiate can develop into tumors

If the cells don't get enough vitamin A stored, the retinoic acid receptor doesn't get activated, cells don't differentiate and they can turn cancerous.

Through working with human and mouse breast cells, scientists found that the problem stemmed from the cellular retinol-binding protein I (CRBP-I), which is involved in the process of storing the vitamin. One scientist added, "We found that, in the early stages of tumor formation, if you don't have CRBP or LRAT [another protein] to store the retinol, it's likely the receptors will not work in a normal way. This means that cells can't differentiate, and therefore start to proliferate into tumors."

Journal of the National Cancer Institute January 5, 2005;97(1):1



Dr. Mercola Dr. Mercola's Comments:

Vitamin A is a wonderful nutrient that many of us do not receive enough of. However, it is important to supplement this vitamin with natural sources. If you regularly read my newsletter, you already know one of the best sources of vitamin A is cod liver oil.

Since too much vitamin A can be toxic and can result in adverse health conditions (breast cancer in addition to birth defects, liver abnormalities, and reduced bone mineral density), many people are afraid of taking too much of this nutrient.

What is rarely addressed, however, and must be considered along with these warnings, is the type of vitamin A being consumed. There is a big difference between synthetic vitamin A and vitamin A from natural sources. Most cases of vitamin A toxicity result from an excess intake of synthetic vitamin A supplements, NOT the natural form of retinol (vitamin A) found in cod liver oil.

When choosing cod liver oil, it is important to remember that not all brands are the same. You will want to do a little homework so you can determine the quality of the omega-3 cod liver oil you consume.

  1. Make sure that your brand is free of mercury and PCBs. This will not be on the label so you will need to:

    • Contact the manufacturer for their analysis
    • Review an independent third party that has analyzed the product
    • Hire a company to test the product yourself.
  2. Confirm that there are very low oxidation products in the cod liver oil.

    Cod liver oil has long-chain unsaturated fats (primarily EPA and DHA) and they are very susceptible to oxidation or damage. If the oil is not processed properly damage will occur. Many years ago nearly all the fish oils were oxidized. That is why when you mention cod liver oil to most anyone they turn up their nose in disgust. Typically, they only taste bad when they are oxidized.

  3. Make certain your cod liver oil has therapeutic levels of vitamin E in it.

    Because cod liver oils are very susceptible to oxidation and rancidity, nearly all manufacturers insert a small amount of one unit of vitamin E per teaspoon. This is sufficient to prevent oxidation of the oil in the bottle. However, after you consume it this is woefully inadequate. Your body will tend to oxidize the oil and much larger doses of vitamin E are needed to prevent it from going rancid in your body.

    You can save yourself the time and expense though as I have paid the money on a number of occasions to randomly test Carlson's brand of cod liver oil and I found it to be free of mercury, PCBs and dioxin. It is the brand that I use in my office and you can get it at your local health food store or on our site.

    Also, Living Fuel Pure D & A Sunshine Gel Caps provide an amazing, safe source of vitamin A -- as well as Vitamin D -- for everyone in your family. Each capsule has the equivalent of one teaspoon of cod liver oil, without the omega-3 fats, Pure D&A is not factory made It is an all-natural product and the distillation process removes all the mercury, PCBs and dioxins.. Because Pure D&A is derived from cod liver oil, it also has the highest-quality natural form of vitamin A, not synthetic vitamin A.

Additional Sources of Vitamin A

Including these foods in your diet should give you adequate vitamin A with no need for supplementation and little to no risk of overdosing. Vitamin A is a fat-soluble vitamin, which means that it requires fat in order to be optimally absorbed.

One of the wonderful characteristics of natural foods is that they nearly always account for variables that could interefere with absorption or contribute to toxicity. You'll notice that all of the foods above also contain fats, so the environment is naturally right for the vitamin A to be utilized by your body.

Related Articles:

Too Much Vitamin A Can Up Risk of Hip Fracture

Vitamin A Is Saving Children's Lives

Vitamin A Improves Growth of Sick Children

Vitamin A -- A Vital Nutrient

Who Needs Vitamins?

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