Women may be stuck in a rock and a hard place when it comes to
removing their ovaries: This new study reveals that women
who have had both their ovaries removed are at twice the normal
risk of developing Parkinson's disease.
This is because significant amounts of the hormone estrogen, which
has been found to protect certain types of nerve cells, are produced
by women's ovaries. Among the nerve cells estrogen helps are those
found in the substantia nigra (a sector of the brain that controls
voluntary movements). Parkinson's patients show degeneration in
this region of the brain, resulting in shaking and unsteadiness,
both characteristic of the condition.
The Parkinson's Link
In order to understand how surgical removal of the ovaries influences
a woman's chance of developing Parkinson's disease or its symptoms,
researchers searched through medical records that dated from 1950-1987.
The team also conducted thousands of medical checks over the past
five years to follow up patients among the 5,000 women involved
in the study.
They found:
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About half of the women surveyed had at least one ovary removed
and some 1,200 had both of them removed.
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Of those who had the procedure (either one or both ovaries
removed), 43 women showed Parkinson's-like symptoms, and 25
of them developed the full-stage disease.
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Only 18 of the roughly 2,500 women whose ovaries were not removed
contracted Parkinson's; 29 developed symptoms.
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Getting both ovaries removed placed women at a higher risk
of developing Parkinson's.
Nature
April 14, 2005
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