For those who think a low-fat diet is the best way to lose weight
... think again. That's because the "old" fat
stored in the body's peripheral tissues -- belly, backside and
thighs -- can't be burned efficiently unless "new"
fat is eaten or generated in the liver, according to researchers.
A team developed mice that were genetically engineered to be absent
of an important fat-synthesizing enzyme in the liver. Consequently,
the mice were unable to produce new fatty acids in the liver, which
presented a problem for the mice, as liver fatty acids are vital
for maintaining normal metabolism for:
Moreover, when the mice were placed on a no-fat diet, they developed
fatty liver disease (their livers filled quickly with fat) and suffered
from low sugar levels; and because their livers were unable to burn
the old fat, extra pounds were accumulated.
The Liver Needs "New" Fat
Based on their findings, researchers found that in order to regulate
fat burning the liver must receive "new" fat -- the fat
that is consumed in food or freshly made in the liver as glucose
is converted to fat by fatty acid synthase. Researchers also saw
the effect of added dietary fat could be duplicated when the mice
were treated with a drug that activated the PPAR-alpha found in
all mammals and central to metabolic processes that extract energy
from dietary components like carbohydrates and fats.
Thus, those who strive to lose fat stored in the peripheral tissues
may find promise in consuming small amounts of dietary fats that
could effectively activate PPAR-alpha and fat burning pathways through
the liver.
Cell
Metabolism May 2005;1(5):Pages 309-322
Science
Blog May 9, 2005
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